PBRC Researchers Are Co-authors on Landmark Publication
A September 1 publication in Nature Methods, “TRANSLON: a single term for translated regions”including Drs. Marla Berry and Lucia Seale of PBRC as co-authors, along with an international cadre of collaborators, proposes new terminology to refer to the translated region of a gene or mRNA, without reference to the sequence or product. The Translon replaces a range of inconsistently defined terms, including open reading frame (ORF), coding DNA sequence (CDS), protein coding region and others. The paper arises from a workshop in May 2024, at which one hundred researchers from 17 countries gathered in the scenic countryside in Bantry, County Cork, Ireland for 5 days of scientific exchange at the EMBO Workshop “Recoding and the diversity of genetic coding”. Topics covered by the 32 speakers and 43 poster presenters included evolution of genetic code variants, ribosomal frameshifting, stop codon readthrough, incorporation of non-standard proteinogenic amino acids, and translational bypassing. Dr. Seale was an invited speaker and Dr. Berry was a Co-organizer and Session Chair. The new terminology proposed herein will be incorporated into the molecular biology lexicon* worldwide.
Online Version: https://rdcu.be/eEaVM