| 5
G12 RR/AI03061-13 (Mortimer) |
09/30/96 - 08/31/01 |
| NIH/NCRR |
$4,915,898 (UHM-RCMI Activity 3) |
Selective Excellence
in Health-Related Research. Activity 3 - Human
Retroviruses and Other Emerging Pathogens
The goals of this RCMI-funded activity are to
further integrate the clinical and basic science
infrastructure of the Hawaii AIDS Research Program;
to further expand and implement a multidisciplinary
research agenda on human retroviruses and AIDS-related
disorders, as well as new, emerging and re-emerging
infectious diseases affecting Asians and Pacific
Islanders and other ethnic minority groups; to
mentor and support a cadre of clinical and basic
science investigators to develop hypothesis-driven
research proposals on human retroviruses and other
emerging pathogens for independent funding; and
to facilitate professional development and training
of ethnic minority investigators, as well as under-represented
students, from Asia and the Pacific. |
| |
|
IMRIE, ALLISON
ACTIVE |
|
| 1 U54 NS39406
(Rayner) |
09/30/99 to 08/31/04 |
| NIH/NINDS |
$1,726,607 |
Specialized Neurosciences
Research Programs
MHC class 1-restricted, anti-HIV-1-specific CD8+
cytotoxic T lymphocyte (CTL) responses in the
central nervous system of HIV-1-infected subjects
The goal of this project is to study the mechanisms
underlying pathogenesis of progressive multifocal
leukoencephalopathy
HIV-associated cognitive impairment is due to
loss of control of HIV replication within the
CNS, that this loss of control is a consequence
of viral escape from CTL responses, and that viral
escape from immune control results in selection
for unique strains of HIV-1 within the CNS of
patients with AIDS dementia complex. Advance neuroscience
research as well as graduate education at the
UH
|
| |
|
LU,
YUNAN
ACTIVE |
|
| Medical
Research Project |
6/1/99 - 5/31/03 |
|
Hawaii Community Foundation |
$172,736 |
Isolation
and Characterization of a Novel Herpesvirus from
Green Turtles with Fibropapilloma
|
| Aquaculture
Pilot Project |
7/1/00 - 6/30/04 |
Center for Tropic and Subtropic Aquaculture
|
$123,595 |
|
Virology
Health Services for Hawaiian Aquaculture
|
| Clinical
Research Center, RCMI-UH |
$10,000
9/1/02 - 8/31/04 |
| Hawaii
Community Foundation |
$51,640 8/1/02 - 7/31/03 |
Development
of a Novel gene Therapy Approach to HIV Infection:
Mutant tRNA Strategy
|
| S11
NS043499-01 |
9/1/02-8/31/07 |
| NINDS,
NIH |
$1,461,529 |
| Development
of Gene Transfer Approaches for NeuroAIDS
|
|
PENDING
| Sea Grant |
10/1/02-9/31/04 |
| University of Hawaii College
Program |
$91,839 |
Development of Immunological Method for Rapid
and Early Detection and Diagnosis of Taura Syndrome
Virus.
OVERLAP
None
|
| NERURKAR,
VIVEK R. |
|
| ACTIVE |
|
| S11
NS41833-01 |
09/28/00 to 08/31/05 |
| NIH/NINDS |
$1,255,862 |
Collaborative
Neurological Sciences Award
Genetic Determinants of JC Virus Replication and
Pathogenicity
The goal of this project is to study the mechanisms
underlying
pathogenesis of progressive multifocal leukoencephalopathy
|
| HCF435393/434929 |
07/01/99 - 08/30/01 |
| Hawaii
Community Foundation |
$59,275 |
Molecular
analysis of hepatitis C virus in injection drug
users and in individuals co-infected with human
immunodeficiency virus in Hawaii
The goal of this project is to analyze hepatitis
C virus in injection drug users and in individuals
co-infected with human immunodeficiency virus
in Hawaii at the molecular level.
|
| RCRII
Pilot Project Grant (Easa) |
02/01/99-03/31/01 |
| NIH/NCRR |
$10,000 |
Prevalence
of early natural history of a recently described
post-transfusion hepatitis-associated DNA virus
(TTV) in multiply transfused infants and children
The goal of this project is to determine the prevalence
of TT virus infection among multiply transfused
pediatric patients.
|
SHIRAMIZU, BRUCE
T.
ACTIVE
|
|
| RR
99005 (Easa) |
10/01/99-09/30/02 |
| Center
of Clinical Research Excellence |
$186,846 (Year 2) |
HIV-1-Associated
Lipodystrophy and Metabolic Abnormalities: Efficacy
and Safety of Testosterone Administration
The major goal of the grant is to promote research
excellence through the support of junior investigators.
Dr. Shiramizu's effort on the grant is to provide
mentorship to Dr. C. Shikuma whose project is
to evaluate the impact of testosterone on glucose
and lipid metabolism and explore the pathophysiologic
mechanisms underlying metabolic abnormalities
in HIV-infected individuals.
|
| 5U01
A134853-08 (Shikuma) |
01/01/00 - 12/31/04 |
| NIAID |
$7,629,385 |
Hawaii
Adult AIDS Clinical Trials Unit
Major goal is focused on large studies evaluating
antiretroviral therapies, treatment and prophylaxis
of opportunistic complications, and immune-based
interventions in a multi-center research setting.
|
| |
|
| PENDING |
|
| Collaborative
Neurosciences Program |
01/01/01-12/31/05 |
| NINDS |
NIH $1,057,740 |
Role of
Macrophages in Elderly AIDS Dementia
The major goal of the program grant is to develop
and establish research excellence in the area
of HIV-associated NeuroAIDS in Hawaii. Dr. Shiramizu's
project is one of 3 proposed project in the grant.
The program is designed to establish collaborations
with other senior investigators at major institutions.
His collaboration is with Dr. Suzanne Gartner
(Johns Hopkins) and they will be looking at the
role of macrophages as a pathogenic player in
dementia in the elderly.
Overlap: None
|
| YANAGIHARA,
RICHARD |
|
| ACTIVE |
|
| Grant-In-Aid |
04/01/00-03/31/01 |
| Japan
Foundation for AIDS Prevention |
8,000,000
yen |
Molecular
Epidemiology of Human Immunodeficiency Virus Type
1 Infection and Population Genetics of Chemokine
Receptor Polymorphisms in Oceania
The goal of this international collaborative project
is to determine the genetic diversity of HIV-1
and the genotype and allele frequencies of chemokine
receptor polymorphisms associated with relative
resistance to HIV-1 infection and slow disease
progression in indigenous populations in Oceania.
|
| WAF
197 (99-018) |
09/01/99-08/31/01 |
| World
AIDS Foundation |
$110,000 |
Maximizing
the Benefits of HIV/STD Prevention Efforts among
High-Risk Women and their Partners in Southern
Vietnam
The principal goal of this multi-institutional
collaborative project is to conduct a community
intervention trial comparing two HIV/STD prevention
approaches: one focusing exclusively on sex workers
and the other simultaneously reaching out to both
sex workers and their clients or partners; in
addition, this project aims to expand Vietnam's
capacity at both national and provincial levels
to evaluate the efficacy and cost-effectiveness
of prevention efforts, thereby strengthening its
overall capability to effectively respond to the
epidemic spread of HIV.
OVERLAP
None
|
|
|
