Vivek R. Nerurkar, Ph.D.

Retrovirology Research Laboratory

Atherton Building, Leahi Hospital, Second Floor

3675 Kilauea Avenue, Honolulu, Hawaii 96816

TEL (808) 732-7702

FAX (808)735-3682
e-mail:  nerurkar@hawaii.edu
Education
1980 B.Sc. Biology, Chemistry, Physics; First Class; University of Bombay, Bombay, India
1981 D.M.L.T. Diploma in Medical Laboratory Technology; University of Bombay, Bombay, India
1983 M.Sc. Zoology (Animal Physiology); First Class; University of Bombay, Bombay, India
1987 Ph.D. Applied Biology (Cell & Molecular Biology); Cancer Research Institute, University of Bombay, Bombay, India
   

Professional History

1981 Technical Assistant, Dept. of Pathology & Clinical Biochemistry, L.T. Medical College and Hospital, Bombay, India
1981-83  Technical Assistant, Indian Red Cross, Bombay, India
1987 Research Associate, Department of Cell & Developmental Pathology, Cancer Research Institute, Bombay, India
1987-89  Research Associate, Cancer Center, University of Rochester, Rochester, New York
1989 Postdoctoral Fellow, Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY
1989-92 Visiting Fellow, Fogarty International Center (FIC), Laboratory of Central Nervous System Studies (LCNSS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland
1992-93 Visiting Associate, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland
1993-94 Guest Researcher, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland
1994-96 Assistant Researcher Virology, Retrovirology Research Laboratory (RRL), Pacific Biomedical Research Center (PBRC), University of Hawaii at Manoa (UHM), Honolulu, Hawaii
1995 Acting Director, RRL, PBRC, UHM, Honolulu, Hawaii
1996- Associate Researcher Virology, RRL, PBRC, UHM, Honolulu, Hawaii
1996-00 Associate Professor, Interdisciplinary Biomedical Sciences Graduate Program, UHM, Honolulu, Hawaii.
1998-99 Member of the Hepatitis Working Group of the Virology Pathogen Study Group, Adult AIDS Clinical Trials Group, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland
1999- Member of the Hawaii Advisory Committee for Elimination of Tuberculosis, Subcommittee on Tuberculosis Diagnostic Laboratory Issues, Hawaii Department of Health, Honolulu, Hawaii.
2000- Associate Professor, Cellular and Molecular Biology Graduate Program, and Tropical Medicine and Medical Microbiology Department Graduate Program, Graduate Division, UHM, Honolulu, Hawaii.



Honors and Awards

1980 Ruia Prize for First Class at B.Sc., University of Bombay, Bombay, India
1980-83 Government open merit scholarship for three consecutive years, University of Bombay, Bombay, India
1983-86 Junior Research Fellowship; Cancer Research Institute, Bombay, India
1986-87 Senior Research Fellowship; Lady Tata Memorial Trust (LTMT), Cancer Research Institute, Bombay, India
1998 Elected as a Fellow of the Infectious Diseases Society of America


Bibliography

  1. Ishwad CS, Ishwad PC, Desai SS, Nerurkar VR, Balkrishnan V and Naik SN. Study of lactate dehydrogenase, haemoglobins and haptoglobins in three endogamous groups of western India. Indian Journal of Medical Research 1986;84:390-397.
  2. Nerurkar VR, Seshadri R, Mulherkar R, Ishwad CS, Lalitha VS and Naik SN. Receptors for epidermal growth factor and estradiol in canine mammary tumours. International Journal of Cancer 1987;40:230-232.
  3. Ishwad CS, Nerurkar VR, Balkrishnan V, Undevia JV and Naik SN. Study of immunogenetics, abnormal haemoglobins and enzymopathies in three endogamous caste groups of western Maharashtra. Indian Journal of Haematology 1988;6:139-144.
  4. Nerurkar VR, Chitale AR, Jalnapurkar BV, Naik SN and Lalitha VS. Comparative pathology of canine mammary tumours. Journal of Comparative Pathology 1989;101:389-397.
  5. Nerurkar VR, Ishwad CS, Seshadri R, Naik SN and Lalitha VS. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in normal canine mammary gland and in mammary tumours and their correlation with estrogen receptors. Journal of Comparative Pathology 1990;102:191-195.
  6. Naik SN, Nerurkar VR, Lalitha VS, Chitale AR, Ishwad CS and Jalnapurkar BV. Mammary tumours in dogs and their similarities with human breast cancer. In: Bamji MS, ed., Proceedings of Symposium on Animal Models in Biomedical Research, Laboratory Animal Information Service Center, NIN, ICMR, India, 1990; pp. 35-40.
  7. Yanagihara R, Nerurkar VR, Garruto RM, Miller MA, Leon-Monzon ME, Jenkins CL, Sanders RC, Liberski PP, Alpers MP and Gajdusek DC. Characterization of a variant of human T-lymphotropic virus type I isolated from a healthy member of a remote, recently contacted group in Papua New Guinea. Proceedings of the National Academy of Sciences, U.S.A. 1991;88:1446-1450.
  8. Yanagihara R, Ajdukiewicz AB, Nerurkar VR, Garruto RM and Gajdusek DC. Verification of HTLV-I infection in the Solomon Islands by virus isolation and gene amplification. Japanese Journal of Cancer Research 1991;82:240-244.
  9. Yanagihara R, Nerurkar VR and Ajdukiewicz AB. Comparison between strains of human T-lymphotropic virus type I isolated from inhabitants of the Solomon Islands and Papua New Guinea. Journal of Infectious Diseases 1991;164:443-449.
  10. Nerurkar VR, Miller MA, Leon-Monzon ME, Ajdukiewicz AB, Jenkins CL, Sanders RC, Godec MS, Garruto RM and Yanagihara R. Failure to isolate human T-lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate Western blot. Journal of General Virology 1992;73:1805-1810.
  11. Nerurkar VR and Yanagihara R. Specificity of an oligonucleotide primer pair and of a single-base substitution in the amplification and detection of env gene sequences of HTLV-I variants from Papua New Guinea and the Solomon Islands. AIDS Research and Human Retroviruses 1992;8:1199-1200.
  12. Lal RB, Rudolph DL, Nerurkar VR and Yanagihara R. Humoral responses to the immunodominant gag and env epitopes of human T-lymphotropic virus type I among Melanesians. Viral Immunology 1992;5:265-272.
  13. Liberski PP, Nerurkar VR, Yanagihara R and Gajdusek DC. Immunohistochemistry of astrocytic reaction. In: Liberski PP, ed., Light and Electron Microscopic Neuropathology of Slow Virus Disorders. Boca Raton, Florida: CRC Press, Inc., 1992:233-250.
  14. Nerurkar VR, Song KJ, Babu PG, Melland RR, Saraswathi NK, Chandy M, Gnanamuthu C, Godec MS, John TJ and Yanagihara R. Sequence analysis of human T-cell lymphotropic virus type I strains from southern India: Gene amplification and direct sequencing from whole blood blotted onto filter paper. Journal of General Virology 1993;74:2799-2805.
  15. Nerurkar VR, Song KJ, Saitou N, Melland RR and Yanagihara R. Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and Solomon Islands. Virology 1993;196:506-513.
  16. Babu PG, Gnanamuthu C, Saraswathi NK, Nerurkar VR, Yanagihara R and John TJ. HTLV-I-associated myelopathy in south India. AIDS Research and Human Retroviruses 1993;9:499-500.
  17. Dueñas-Barajas E, Bernal JE, Vaught DR, Nerurkar VR, Sarmiento P, Yanagihara R and Gajdusek DC. Human retroviruses in Amerindians of Colombia: High prevalence of human T-cell lymphotropic virus type II infection among the Tunebo Indians. American Journal of Tropical Medicine and Hygiene 1993;49:657-663.
  18. Nerurkar VR, Song KJ, Gajdusek DC and Yanagihara R. Genetically distinct hantavirus in deer mice. Lancet 1993;342:1058-1059.
  19. Nerurkar VR, Wakayama I, Rowe T, Yanagihara R and Garruto RM. Preliminary observations on in vitro toxicity of N-butylbenzylsulfonamide: A newly discovered neurotoxin. In: Johannessen JN, ed., Annals of the New York Academy of Sciences 1993;679:280-287.
  20. Wakayama I, Nerurkar VR and Garruto RM. Immunocytochemical and ultrastructural evidence of dendritic degeneration in motor neurons of aluminum-intoxicated rabbits. Acta Neuropathologica (Berlin) 1993;85:122-128.
  21. Liberski PP, Yanagihara R, Nerurkar VR and Gajdusek DC. Tumor necrosis factor-a produces Creutzfeldt-Jakob disease-like lesions in vivo. Neurodegeneration 1993;2:215-225.
  22. Song KJ, Nerurkar VR, Saitou N, Lazo A, Blakeslee JR, Miyoshi I and Yanagihara R. Genetic analysis and molecular phylogeny of simian T- cell lymphotropic virus type I: Evidence for independent virus evolution in Asia and Africa. Virology 1994;199:56-66.
  23. Nerurkar VR, Song KJ, Bastian IB, Garin B, Franchini G and Yanagihara R. Genotyping of human T-cell lymphotropic virus type I using Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: Insights into virus evolution and dissemination. Journal of Infectious Diseases 1994;170:1353-1360.
  24. Nerurkar VR, Song KJ, Song JW, Nagle JW, Hjelle B, Jenison S and Yanagihara R. Genetic evidence for a hantavirus enzootic in deer mice (Peromyscus maniculatus) a decade before the recognition of hantavirus pulmonary syndrome. Virology 1994;204:563-568.
  25. Nerurkar VR, Song KJ, Melland RR and Yanagihara R. Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I variants from Melanesia with and without spastic myelopathy. Molecular Neurobiology 1994;8:155-173.
  26. Strong MJ, Mao K, Nerurkar VR, Wakayama I, Yanagihara R and Garruto RM. Dose-dependent selective suppression of light (NFL) and medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity. Molecular and Cellular Neurosciences 1994;5:319-326.
  27. Liberski PP, Yanagihara R, Nerurkar VR and Gajdusek DC. Further ultrastructural studies of lesions produced in the optic nerve by tumor necrosis factor (TNF-a): A comparison with experimental Creutzfeldt-Jakob disease. Acta Neurobiol. Experimental (Warsz) 1994;5:319-326.
  28. Song KJ, Nerurkar VR, Pereira-Cortez AJ, Yamamoto M, Taguchi H, Miyoshi I and Yanagihara R. Sequence and phylogenetic analyses of human T-cell lymphotropic virus type I from a Brazilian native with adult T-cell leukemia: Comparison with virus strains from South America and the Caribbean basin. American Journal of Tropical Medicine and Hygiene 1995;52:101-108.
  29. Nerurkar VR, Song KJ, Achiron A, Melland RR, Hamiel O, Shohat B, Melamed E and Yanagihara R. Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: Genetic and phylogenetic evidence for common source of infection. Journal of Medical Virology 1995;45:361-366.
  30. Yanagihara R, Saitou N, Nerurkar VR, Song KJ, Bastian I, Franchini G and Gajdusek DC. Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration. Cellular and Molecular Biology 1995;41 (suppl. I), S145-S161.
  31. Switzer WM, Owen SM, Pieniazek DA, Nerurkar VR, Dueñas-Barajas E, Heneine W and Lal RB. Molecular analysis of human T-cell lymphotropic virus type II from the Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb. Virus Genes 1995;10:153-162.
  32. Liberski PP, Nerurkar VR, Yanagihara R and Gajdusek DC. Tumor necrosis factor (TNF-a) is involved in the pathogenesis of the panencephalopathic type of Creutzfeldt-Jakob disease. Molecular Chemical Neuropathology 1995;24:223-225.
  33. Nerurkar VR, Nguyen HT, Dashwood M, Hoffmann PR, Yin CQ, Morens D, Kaplan AH, Detels R and Yanagihara R. HIV type 1 E in commercial sex workers and injection drug users in southern Vietnam. AIDS Research and Human Retroviruses 1996;12:841-843.
  34. Kordek R, Nerurkar VR, Liberski PP, Isaacson S, Yanagihara R and Gajdusek DC. Heightened expression of tumor necrosis factor-µ , interleukin-1µ and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. Proceedings of the National Academy of Sciences, U.S.A. 1996;93:9754-9758.
  35. Wakayama I, Nerurkar VR, Strong MJ and Garruto RM. Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis. Acta Neuropathologica (Berlin) 1996;92:545-554.
  36. Wakayama I, Song K-J, Nerurkar VR, Yoshida S and Garruto RM. Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum. Brain Research 1997;748:237-240.
  37. Nerurkar VR, Nguyen HT, Woodward CL, Hoffmann PR, Dashwood W-M, Long HT, Morens DM, Detels R and Yanagihara R. Sequence and phylogenetic analyses of HIV-1 infection in Vietnam: subtype E in commercial sex workers and injection drug users. Cellular and Molecular Biology 1997;43:959-968.
  38. Nerurkar VR, Wu Z, Dashwood WM, Woodward CL, Zhang M, Detels R and Yanagihara R. Complete nef gene sequence of HIV type 1 subtype B’ from professional plasma donors in the Peoples’s Republic of China. AIDS Research and Human Retroviruses 1998;14:461-464.
  39. Nerurkar VR, Chua PK, Hoffmann PR, Dashwood WM, Shikuma CM and Yanagihara R. High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission. Journal of Medical Virology 1998;56:123-127.
  40. Nerurkar VR, Chua PK, Shikuma CM, Dashwood W-M, Milne C, Woodward CL, Kobayashi G, Peterson J and Yanagihara R. Precipitous decline in IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS. Hawaii Medical Journal 1998;57:11-12.
  41. Gonzalez S, Tirado G, Revuelta G, Yamamura Y, Lu Y, Nerurkar VR and Yanagihara R. CCR5 chemokine receptor genotype frequencies among Puerto Rican HIV-1-seropositive individuals. Bol. Asoc. Med P R 1998;90:12-15.
  42. Bertrand E, Lewandowska E, Nerurkar VR, Bratosiewicz J, Yanagihara R, Zaborski J, Liberski PP. Progressive multifocal leukoencephalopathy (PML) and cerebral toxoplasmosis in an adult patient, with no symptoms of underlying immunosuppressing illness. Folia Neuropathol 1998;36(4):229-234.
  43. Nerurkar VR, Woodward CL, Nguyen HT, Miller FD, Tashima LT, Zalles-Ganley A, Chua PK, Peterson JE, Chi PK, Long HT, Detels R and Yanagihara R. Lack of association between a recently described post-transfusion hepatitis-related DNA virus, TT virus, among individuals at-risk for hepatitis C virus and human immunodeficiency virus type 1 in Vietnam. International Journal of Infectious Diseases 1999;3(4):186-191.
  44. Lu Y, Nerurkar VR, Dashwood W-M, Woodward CL, Ablan S, Shikuma CS, Grandinetti A, Chang H, Nguyen HT, Wu Z, Yamamura Y, Boto WO, Merriwether A, Kurata T, Detels R and Yanagihara R. Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders. International Journal of Infectious Diseases 1999;3(4):181-185.
  45. Lu Y, Nerurkar VR, Aguirre AA, Work TM, Balazas GH and Yanagihara R. Establishment and characterization of 13 cell lines from a green sea turtle (Chelonia mydas) with fibropapillomas. In Vitro Cell and Developmental Biology - Animal 1999;35:389-393.
  46. Chua PK, Nerurkar VR, Yu Q, Woodward CL, Melish M and Yanagihara R. No etiological association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C/hepatitis G virus or Chlamydia pneumoniae. The Pediatric Infectious Diseases Journal 2000;19:477-479.
  47. Lu Y, Yu Q, Zamzow JP, Wang Y,Losey GS, Balazas GH, Nerurkar VR and Yanagihara R. Detection of green turtle herpesviral sequence in saddleback wrasse: A possible mode of transmission of green turtle fibropapilloma. Journal of Aquatic Anima Health 2000;12(1):58-63.
  48. Lu Y, Aguirre AA, Work TM, Balazas GH, Nerurkar VR, and Yanagihara R. Identification of a small, naked virus in tumor-like aggregates in cell lines derived from a green turtle, Chelonia mydas, with fibropapillomas. Journal of Virological Methods 2000;86:25-33.
  49. Yu Q, Lu Y, Nerurkar VR, and Yanagihara R. Amplification and analysis of DNA flanking known sequences of a novel herpesvirus from green turtles with fibropapilloma. Archives of Virology 2000;145:1-8.
  50. Lu Y, Wang Y, Yu Q, Aguirre AA, Work TM, Balazas GH and Nerurkar VR, Yanagihara R. Detection of herpesviral sequences in tissues and organs of green turtles with fibropapilloma. Archives of Virology 2000;145:1885-1893..
  51. Yu Q, Lu Y, Nerurkar VR, and Yanagihara R. Turtle tumor susceptibility gene TSG101: Full-length cDNA sequence, genomic architecture, and absence of abnormal transcript in GTFP. Archives of Virology (in press).
  52. Lin C-L, Kyono W, Tongson J, Chua PK, Easa D, Yanagihara R and Nerurkar VR. Detection of a novel human circovirus, TT virus (TTV) in feces of healthy children. Clinical and Diagnostic Laboratory Immunology 2000;7:960-963.
  53. Cobo MF, Jobes DV, Yanagihara R, Nerurkar VR, Ryschkewitsch CF, Yamamura Y and Stoner GL. Reconstructing population history using JC virus: Amerinds, Spanish and Africans in the ancestry of modern Puerto Ricans. Human Biology (in press).