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Professional Experience
| 1972-1974 |
Intern and Resident, Pediatrics, University of Colorado, Denver |
| 1974-1976 |
Research Associate, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda |
| 1976-1977 |
Resident, Pediatrics, University of California at San Francisco
1977-1979 Fellow in Infectious Diseases, Pediatrics, University of Colorado, Denver |
| 1977-1979 |
Fellow in Infectious Diseases, Department of Pediatrics, University of Colorado, Denver |
| 1979-1982 |
Research Physician, NINCDS Research Center,
Tamuning, Guam
1982-1984 Special Expert, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda |
| 1982-1984 |
Special Expert, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda |
| 1985-1995 |
Medical Director (tenured, Research Officer Group) and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda and Frederick |
| 1995-2002 |
Director, Retrovirology Research Laboratory, and Leader, Human Retroviruses and Other Emerging Pathogens Activity, Pacific Biomedical Research Center, University of Hawaii at
Manoa, Honolulu |
| 2000-present |
Director, RCMI Program, Pacific Biomedical Research Center, University of Hawaii at
Manoa, Honolulu |
| 2002-present |
Professor, Departments of Pediatrics, Public Health Sciences and Epidemiology, and Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii at Manoa |
| Honors: |
1990 Outstanding Service Medal, U.S. Public Health Service; 1991 Bailey K. Ashford Medal, American Society of Tropical Medicine and Hygiene; 1993 Meitorious Service Medal, U.S. Public Health Service |
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Selected Publications (from 195 peer-reviewed journal articles, 33 chapters, and 1 monograph)
- Yanagihara RT, Asher DM, Gibbs CJ Jr, Gajdusek DC. Attempts to establish cell cultures infected with the viruses of subacute spongiform encephalopathies. Proceedings of the Society for Experimental Biology and Medicine 1980;165: 298-305.
- Perl DP, Gajdusek DC, Garruto RM, Yanagihara RT, Gibbs CJ Jr. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Science 217, 1053-1055, 1982.
- Yanagihara RT, Garruto RM, Gajdusek DC. Epidemiological surveillance of amyotrophic lateral sclerosis and parkinsonism-dementia in the Commonwealth of the Northern Mariana Islands. Annals of Neurology 1983;13:79-86.
- Yanagihara R, Goldgaber D, Gajdusek DC. Propagation of nephropathia epidemica virus in Mongolian gerbils. Journal of Virology 1985;53:973-975.
- Yanagihara R, Amyx HL, Gajdusek DC. Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). Journal of Virology 1985;55:34-38.
- Nakamura T, Yanagihara R, Gibbs CJ Jr, Gajdusek DC. Immune spleen cell-mediated protection against fatal Hantaan virus infection in infant mice. Journal of Infectious Diseases 1985;151:691-697.
- Yanagihara R, Daum CA, Lee P-W, Baek LJ, Amyx HL, Gajdusek DC, Gibbs CJ Jr. Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA. Transactions of the Royal Society of Tropical Medicine and Hygiene 1987;81:42-45.
- Goudsmit J, Epstein LG, Paul DA, van der Helm HJ, Dawson GJ, Asher DM, Yanagihara R, Wolff AV, Gibbs CJ Jr, Gajdusek DC. Intra-blood-brain-barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees. Proceedings of the National Academy of Sciences, U.S.A. 1987;84:3876-3880.
- Yanagihara R, Amyx HL, Lee P-W, Asher DM, Gibbs CJ Jr, Gajdusek DC. Experimental hantavirus infection in nonhuman primates. Archives of Virology 1988;101:125-130.
- Yanagihara R. Hantavirus infection in the United States: Epizootiology and epidemiology. Reviews of Infectious Diseases 1990;12:449-457.
- Yanagihara R, Silverman DJ. Experimental infection of human vascular endothelial cells by pathogenic and nonpathogenic hantaviruses. Archives of Virology 1990;111:281-286.
- Yanagihara R, Jenkins CL, Alexander SS, Mora CA, Garruto RM. Human T lymphotropic virus type I infection in Papua New Guinea: High prevalence among the Hagahai confirmed by Western analysis. Journal of Infectious Diseases 1990;162:649-654.
- Yanagihara R, Nerurkar VR, Garruto RM, Miller MA, Leon-Monzon ME, Jenkins CL, Sanders RC, Liberski PP, Alpers MP, Gajdusek DC. Characterization of a variant of human T lymphotropic virus type I isolated from a healthy member of a remote, recently contacted group in Papua New Guinea. Proceedings of the National Academy of Sciences, U.S.A . 1991;88:1446-1450.
- Yanagihara R, Ajdukiewicz AB, Garruto RM, Sharlow ER, Wu X-Y, Alemaena O, Sale H, Alexander SS, Gajdusek DC. Human T lymphotropic virus type I infection in the Solomon Islands. American Journal of Tropical Medicine and Hygiene 1991;44:122-130.
- Gessain A, Yanagihara R, Franchini G, Garruto RM, Jenkins CL, Ajdukiewicz AB, Gallo RC, Gajdusek DC. Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands. Proceedings of the National Academy of Sciences, U.S.A . 1991;88:7694-7698.
- Gessain A, Boeri E, Yanagihara R, Gallo RC, Franchini G. Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from Melanesia: genetic and phylogenetic relationship with HTLV-I strains from other geographical regions. Journal of Virology 1993;67:1015-1023.
- Nerurkar VR, Song KJ, Song JW, Nagle JW, Hjelle B, Jenison S, Yanagihara R. Genetic evidence for a hantavirus enzootic in deer mice (Peromyscus maniculatus) a decade before the recognition of hantavirus pulmonary syndrome. Virology 1994;204:563-568.
- Song K-J, Nerurkar VR, Saitou N, Lazo A, Blakeslee JR, Miyoshi I, Yanagihara R. Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. Virology 1994;199:56-66.
- Yanagihara R. Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations. Advances in Virus Research 1994;43:147-186.
- Kordek R, Nerurkar VR, Liberski PP, Isaacson S, Yanagihara R, Gajdusek DC. Heightened expression of tumor necrosis factor- a , interleukin-1 b and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. Proceedings of the National Academy of Sciences, U.S.A. 1996;93:9754-9758.
- Song J-W, Baek LJ, Nagle JW, Schlitter DA, Yanagihara R. Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States. Archives of Virology 1996;141:959-967.
- Song J-W, Baek LJ, Gavrilovskaya I, Mackow ER, Hjelle B, Yanagihara R. Sequence analysis of the complete S genomic segment of a newly identified hantavirus isolated from the white-footed mouse (Peromyscus leucopus): phylogenetic relationship with other sigmodontine rodent-borne hantaviruses. Virus Genes 1996;12:249-258.
- Agostini HT, Yanagihara R, Davis V, Ryschkewitsch CF, Stoner GL. Asian genotypes of JC virus in Native Americans and in a Pacific Island population: markers of viral evolution and human migration. Proceedings of the National Academy of Sciences, U.S.A. 1997;94:14542-14546.
- Song J-W, Baek LJ, Kim SH, Kho EY, Kim JH, Lee YJ, Yanagihara R, Song K-J. Genetic diversity of Apodemus agrarius-borne Hantaan virus in Korea. Virus Genes 2000;21:227-232.
- Lin C-L, Kyono W, Tongson J, Chua PK, Easa D, Yanagihara R, Nerurkar VR. Detection of a novel human circovirus, TT virus, in feces of healthy children. Clinical and Diagnostic Laboratory Immunology 2000;7:960-963.
- Fernandez Cobo M, Jobes DV, Yanagihara R, Nerurkar VR, Yamamura Y, Ryschkewitsch CF, Stoner GL. Reconstructing population history with JC virus: Amerinds, Spanish and Africans in the ancestry of modern-day Puerto Ricans. Human Biology 2001;73:385-402.
- Song J-W, Gligic A, Yanagihara R. Identification of Tula hantavirus in Pitymys subterraneus captured in the Cacak region of Serbia-Yugoslavia. International Journal of Infectious Diseases 2002;6:31-36.
- Yanagihara R, Nerurkar VR, Scheirich I, Agostini HT, Mgone CS, Cui X, Jobes DV, Cubitt CL, Ryschkewitsch CF, Friedlaender JS, Stoner GL. JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements. Human Biology 2002;74:473-488.
- Chua PK , Melish ME, Yu Q, Yanagihara R, Yamamoto KS, Nerurkar VR. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clinical and Diagnostic Laboratory Immunology 2003;10:308-314.
- Song J-W, Baek LJ, Song K-J, Skrok A, Markowski J, Bratosiewicz J, Kordek R, Liberski PP, Yanagihara R. Characterization of Tula virus from common voles (Microtus arvalis) in Poland: Evidence for geographic-specific phylogenetic clustering. Virus Genes 2004;29:239-247.
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