Pratibha Nerurkar

Assistant Professor

Retrovirology Research Laboratory

Atherton Building, Leahi Hospital, Second Floor

3675 Kilauea Avenue, Honolulu, Hawaii 96816

TEL (808) 732-7702

FAX (808)

email:

   

 

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
Bombay University, India B.S. 1983

Biochemistry, Chemistry
Bombay University, India M.S. 1985 Biochemistry
Bombay University, India Ph.D. 1990 Biochemistry
NCI, National Institutes of Health Post Doc. 1991-94 Chem. and transplacental carcinogenesis
 
Professional Experience
1986-1988 Junior Research Fellow, Cancer Research Institute, Bombay, India
1988-1989

Senior Research Fellow, Cancer Research Institute, Bombay, India

1989 Postdoctoral Fellow, Department of Medicinal Chemistry, State University of New York, at Buffalo, Buffalo, New York
1990-1994 Visiting Fellow, Fogarty International Center, Laboratory of Comparative Carcinogenesis, National Institutes of Health, NCI-FCRDC, Frederick, Maryland
1995 Consultant, Department of Tropical Medicine and Medical Microbiology, School of Medicine, University of Hawaii
1996 Junior Researcher, Retrovirology Research Laboratory (RRL), Pacific Biomedical Research Center (PBRC), University of Hawaii

1996-1997

 Assistant Researcher, Molecular Epidemiology, Cancer Research Center of Hawaii, University of Hawaii (RCUH program)
1997-2001 Assistant Specialist, Molecular Epidemiology, Cancer Research Center of Hawaii, UH
2000-Present Assistant Researcher, RRL, PBRC, UHM, Honolulu Hawaii, USA
2002-Present Assistant Professor, MBBE, CTAHR, UHM, Honolulu, Hawaii, USA

 

Honors and Awards

Gold Medal for securing First Rank, Biochemistry, B.Ss., University of Bombay, Bombay, India, 1984
S.I.E.S. College Prize for receiving highest marks and First Rank in Biochemistry, B.Sc., University of Bombay, Bombay, India, 1984
S.I.E.S. College Prize for receiving highest Marks and Fifth Rank in Zoology, B.Sc., University of Bombay, Bombay, India, 1984
Dr. R.K. Anjaria Memorial Prize for receiving highest marks and First Rank in Biochemistry, M.Sc., University of Bombay, Bombay, India, 1985
Junior Research Fellowship, Cancer Research Institute, Tata Memorial Center, Bombay, India, 1986-1988
Senior Research Fellowship, Cancer Research Institute, Tata Memorial Center, Bombay, India, 1988- 1989

Peer-reviewed publications (selected References out of 21)

  • Gijare, P.S. , Rao, K.V.K., Kandarkar, S.V. and Bhide, S.V. Enhanced expression of tonofilament bundles during hamster cheek pouch carcinogenesis is associated with tumor growth and the loss of high molecular weight keratins. Cell Biology International Reports 1988; 12: 1067-1075.
  • Gijare, P.S. , Rao, K.V.K. and Bhide, S.V. Effects of tobacco-specific nitrosamines and snuff extract on cell proliferation and enzyme activities of ornithine decarboxylase and aryl hydrocarbon hydroxylase in mouse tongue primary epithelial cell cultures. Journal of Cancer Research and Clinical Oncology 1989; 115: 558-563.
  • Gijare, P.S ., Rao, K.V.K. and Bhide, S.V. Modulatory effects of snuff, retinoic acid, and -carotene on DMBA-induced hamster cheek pouch carcinogenesis in relation to keratin expression. Nutrition and Cancer 1990; 14:2 53-259.
  • Gijare, P.S. , Rao, K.V.K. and Bhide, S.V. Inhibitory effects of snuff extract on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in relation to cell proliferation of mouse tongue epithelial cells. Indian Journal of Experimental Biology 1990; 28:1012-1016.
  • Nerurkar, P.V. , Anderson, L.M., Snyderwine, E.G., Park, S.S., Thorgeirsson, S.S. and Rice, J.M. Specific induction of hepatic cytochrome P4501a-2 in C57BL/6 and DBA/2 mice treated with 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Journal of Biochemical Toxicology 1990; 8:175-185
  • Nerurkar, P.V. , Park, S.S., Thomas, P.E., Nims, R.W. and Lubet, R.A. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochrome P4501A2 and 2B, respectively, in the rat and mouse. Biochemical Pharmacology 1993; 46: 933-943.
  • Nerurkar, P.V. , Schut, H.A.J., Anderson, L.M., Riggs, C.W., Snyderwine, E.G., Thorgeirsson, S.S., Weber, W.W., Rice, J.M. and Levy, G.N. DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder and kidney of congenic mice differing in Ah-responsiveness and N-acetyltransferase genotype. Cancer Research 1995; 55: 3043-3049.
  • Anderson , L.M., Chhabra, S.K., Nerurkar, P.V., Souliotis, V.L. and Kyrtopoulos, S.A. Alcohol-related cancer risk: A toxicokinetic hypothesis. Alcohol 1995; 12: 97-104.
  • Nerurkar, P.V. , Schut, H.A.J., Anderson, L.M., Riggs, C.W., Fornwald, L.W., Snyderwine, E.G., Thorgeirsson, S.S., Weber, W.W., Rice, J.M. and Levy, G.N. Ahr Locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the absence of cytochrome P450 induction. Molecular Pharmacology 1996; 49: 874-881.
  • Le Marchand, L., Sivaraman, L., Seifried, A., Lum, A., Franke, A.A., Custer, L.C. and Nerurkar, P.V. Gene-diet interaction and the high colorectal cancer risk of Japanese Americans. 1998 Proceedings of the UICC Symposium on Familial Cancer and Prevention-Molecular Epidemiology: A new Strategy Towards Cancer Control. John Wiley & Sons.
  • Nerurkar, P.V. , Le Marchand, L. and Cooney, R.C. Effects of marinating with Asian marinades or Western barbecue sauce on PhIP and MeIQx formation in barbecued beef. Nutrition and Cancer , 1999; 34: 147-152.
  • Hecht, S.S., Trushin N., Chhabra, S., Anderson, L.M., and Nerurkar, P.V. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cultured monkey lung tissue. Drug Metabolism and Disposition, 2000 ; 28: 5-9.
  • Josyula S., Lu WL-J., Salazar J.J., Nerurkar P.V., Jones A.B., Grady J.J., Snyderwine E. and Anderson L.M.. DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in fetal tissue of patas monkeys after transplacental exposure. Toxicology and Applied Pharmacology, 2000; 116: 151-160.
  • Nerurkar, P.V, Okinaka L., Aoki C., Seifried A., Lum-Jones A., Wilkens L.R. and Le Marchand L. CYP1A1, GSTM1 and GSTP1 genetic polymorphisms and urinary 1-hydroxypyrene excretion in non-occupationally exposed individuals. Cancer Epidemiology, Biomarkers and Prevention, 2000; 9: 1119-1122.
  • Nerurkar, P.V, Shikuma C. and Nerurkar V.R. Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-related lipodystrophy and associated metabolic disorders. Clinical Biochemistry, 2001; 34: 519-129.
  • Le Marchand L., Hankin J.H., Pierce L.M., Sinha R., Nerurkar P.V., Franke A., Wilkens L.P., Kolonel L.N., Donlon T., Seifried A., Custer L.J., Lum-Jones A., Chang W. Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. Mutation Research, 2002; 205: 506-507.
  • Nerurkar, P.V , Pearson L., Frank J.E., Yanagihara R., Nerurkar V.R. HAART-associated lactic acidosis: In vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. Cellular and Molecular Biology 2003; 49:1205-1211.
  • Nerurkar P.V. , Dragull K.D., Tang C.S. Kava-associated hepatic toxicities: kava alkaloids and mitochondrial dysfunction. Toxicological Sciences 2004; 79:106-111.
  • Nerurkar P.V., Pearson L., Efird J., Adeli K., Theriault A. and Nerurkar V.R. Inhibition of microsomal triglyceride transfer protein ( MTP) gene expression and ApoB secretion by bitter melon in HepG2 Cells. Journal of Nutrition, 2005; 135: 702-706.