| Post-Graduate Training |
| 1993-1997 |
Combined Medicine/Pediatrics Residency at Yale School of Medicine-Affiliated Bridgeport, CT |
| 1996-1997 |
Chief Resident of Combined Medicine/Pediatrics Residency at Yale School of Medicine-Affiliated Bridgeport Hospital, Bridgeport, CT |
| 1997-1999 |
General Preventive Medicine Residency at Johns Hopkins School of Hygiene and Public Health |
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| Faculty Appointments/Positions |
| 1999-2003 |
Associate Program Director, Ambulatory Care in HIV Medicine Fellowship Program, Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI |
| 1999-2003 |
Assistant Professor, Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI |
| 2002-2004 |
Associate Program Director, Ambulatory Care in HIV Medicine Fellowship Program, Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI |
| |
|
| Teaching Experience |
| 1998 |
Instructor, Issues in International Health |
| 1999-present |
Attending Physician, Queens Medical Center |
| 2000-present |
Clinical Instructor, Problem Based Learning, John A. Burns School of Medicine, University of Hawaii |
| 2000-present |
Attending Physician, Kapiolani Medical Center for Women and Children |
| |
| Professional
Experience |
| 1998 |
Temporary Staff Physician at ALIVE Clinic, Wood Clinic, Baltimore, MD |
| 1998-1999 |
Temporary Staff Physician at Helixcare, Physicians' Promptcare, Abingdon, MD |
| 1998-1999 |
Temporary Staff Physician at Baltimore Medical System, Baltimore Medical System, Baltimore, MD |
| 1999-present |
Attending Physician, Queen Emma Clinics, Honolulu, HI |
| 2000-present |
Attending Physician/Pediatric Hospitalist, Kapiolani Medical Center for Women and Children, Honolulu, HI |
| 2002 |
Visiting Consultant/Professor, Chubu Hospital, Okinawa, Japan |
|
2002-present |
Firm Director, Queen Emma Clinics, Queen's Medical Center, Honolulu HI |
| |
| Professional Activities |
| 1995 |
Planning Committee for the 19th Annual Workshop of Yale School of Medicine Affliated Hospitals-Ethical Issues in Managed Care |
| 1995 |
Participated in health relief services to the indigent in
Iloilo
City, Philippines |
| 1995-1997 |
House-staff representative, Bridgeport Hospital |
| 1996 |
Provided primary care for Indian Health Service, Pheonix, AZ |
| 1996-1997 |
Coordinator of Project Hope, Bridgeport Hospital, an organization created by the house-staff to provide medical education to the indigent |
| 1997-1998 |
Provided primary care to the indigent at the Shepherd's Clinic, an inner city volunteer health clinic, Baltimore, MD |
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| Professional Membership |
| 1993-present |
Member, American Medical Association |
| 1997-2001 |
Member, American College of Preventive Medicine |
| 1999-2004 |
Member, American College of Preventive Medicine |
| 2002-2004 |
Fellow, American Academy of Pediatrics |
| |
| Certifications |
| HIV Specialist, American Academy of HIV Medicine, 2002 |
| Diplomate, American Board of Internal Medicine, 1997 |
| Diplomate, American Academy of Pediatrics, 2000 |
| Board Eligible, American College of Preventive Medicine, 1999 |
| |
| Licensure |
Maryland Board of Physician Quality Assurance, 1997-1999 |
| State of Hawaii Board of Medical Examiners, 1999-Present |
| |
| National Committees |
| 1999-2002 |
Member, AIDS Clinical Trials Group Outcomes Committee |
| 1999-2002 |
Member, AIDS Clinical Trials Group Resource Use & Cost Effectiveness Subcommittee |
| 1999-2003 |
Outcomes representative, ACTG 5076: HIV-1 Resistance testing during antiretroviral failure: Comparison of sequencing versus phenotyping |
| 1999-2003 |
Protocol Investigator, ACTG 5096: Use of SPECT as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in Subjects Co-Infected with HIV and HCV |
| 2000-present |
Member, Medicine Pediatrics Program Director's Association |
| 2002-present |
Member, Section on Medicine/Pediatrics, American Academy of Pediatrics |
| 2003-present |
Co-Chair, AACTG 5209: The Safety, Efficacy, and Tolerability of Ezetimibe in Combination with Statin Therapy for the Treatment of Elevated LDL Cholesterol in HIV-Infected Subjects |
| |
| Local Committees |
| 1999-present |
Member, Scientific Advisory Board, Hawaii AIDS Clinical Research Program |
| 1999-present |
Member, Residency Committee, Department of Internal Medicine, John A. Burns School of Medicine |
| 2000-present |
Member, Pediatrics Education Subcommittee, Department of Pediatrics, John A. Burns School of Medicine |
| 2001-present |
Member, Residency Review Committee, Department of Pediatrics, John A Burns School of Medicine |
| 2001-present |
Member, Residency Review Committee, Department of Internal Medicine, John A. Burns School of Medicine |
| 2001-Present |
Chair, Combined Internal Medicine/Pediatrics Residency Program selection committee, John A. Burns School of Medicine |
| |
| Memberships |
| 1993-present |
Member, American Medical Association |
| 1997-2001 |
Member, American College of Preventive Medicine |
| 1999-2004 |
Member, American College of Physicians |
| 2002-2004 |
Fellow, American Academy of Pediatrics |
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Honors
and Awards
| 1986 |
Westinghouse Science Talent Search Semifinalist, Decemter 1986 |
| 1988 |
United Hospital Fund Award for Volunteer, Memorial Sloan-Kettering Cancer Center, New York, July 1988 |
| 1992 |
Medical Alumni Fund Award in Preventive Medicine, SUNY Health Science Center at Brooklyn, August 1992 |
| 1995 |
Certificate of Appreciation from the People of Iloilo City, Philippines, February 1995 |
| 1997 |
George Brown Longstreth Humanness Award, Bridgeport Hospital, December 1997 |
| 1998 |
Certificate of Dedication, Migrant Farm Workers Project, Three Lower Counties, Maryland, July 1998 |
| 1998 |
Delta Omega Honor Society, Johns Hopkins School of Public Health and Hygiene, May 1998 |
| 2005 |
University of Hawaii Pediatric Residency Program Faculty Teaching Award 2004-2005 |
Projects (Nationally and locally sponsored)
2003 – Present ACTG Protocol – Principal Investigator of project, A5209: The Safety, Efficacy, and Tolerability of Ezetimibe in Combination with Statin Therapy for the Treatment of Elevated Non-HDL Cholesterol in HIV-Infected Subjects (Ongoing)
2000-Present Local Project - Principal Investigator of project, HARC 006: Descriptive Epidemiologic Study of the Hawaii Sero-Positivity and Medical Management Program (HSPAMM) Participants (Collaboration with the State of Hawaii Department of Health) (Ongoing)
2003 ACTG Proposal – Author PR 428 (Proposal PI): The Safety, Efficacy, and Tolerability of Ezetimibe in Combination with Statin Therapy for the Treatment of Elevated Non-HDL Cholesterol in HIV-Infected Subjects (Funded – changed to AACTG protocol A5209)
2001 Local Project Proposal – Co-Investigator, HACRP 002: Open-Label Pilot Study of the Effect of Vitamin Co-Factors and Anti-Oxidants on Oxidative Stress and on Subcutaneous Adipose Tissue Mitochondrial DNA Content and Gene Expression of Oxidative Phosphorylation Enzymes in HIV-infected Subjects with Peripheral Fat Wasting following Use of Highly Active Anti-Retroviral Therapy (Completed)
2001-2002 Local Project – Co-Investigator, Mitochondrial Toxicity in Umbilical cord Blood and Placenta Samples in HIV Infected Women Receiving Anti-Retrovirals During Pregnancy. Protocol No. 00-81E. (Completed)
2001 ACTG Proposal – Author, PR 354: A Randomized Double-Blind Placebo Controlled Study of L-acetylcarnitine (LAC) for the Treatment of Mild to Moderate Nucleoside Reverse Transcriptase Inhibitor (NRTI) Associated Peripheral Neuropathy (Funded by the CRC – Subsequently withdrew from protocol team to concentrate on other areas of research)
2000 ACTG Proposal - Author, PR 305: Relationship of Fat Re-Distribution & Metabolic Abnormalities to Mitochondrial Toxicity: A Prospective 3 Arm Randomized Double-Blinded Comparative Study of a NNRTI + PI Regimen vs dual NRTI + PI; dual NRTI + NNRTI Regimens as Initial Treatment of HIV Infection (Not funded)
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| Grants and Contracts |
| Pending Grants |
Principal Investigator, Sympathetic modulation of visceral adipose in HIV lipodystrophy. NINDS/NIMH Mentored Research Career Development Awards in AIDS Research.
Principal Investigator, Autonomic Function in Human Immunodeficiency Virus Disease
Goal is to examine the long term changes of autonomic function, glucose homeostasis and body composition in HIV-infected individuals receiving highly active anti-retroviral therapy (HAART) compared to HIV-infected individuals not receiving HAART. American Heart Association.
Co-Investigator, Pilot study of relationship between a novel QTc susceptibility gene and autonomic function. Goal is to determine the autonomic function responses among participants with prolonged QTc will differ among those with different angiotension converting enzyme (ACE) gene polymorphisms. Hawaii Community Foundation.
|
| Current Awards |
Principal Investigator of project, Autonomic Function in HIV-1 Infected Individuals Receiving Highly Active Anti-retroviral Therapy With Abdominal Adiposity. NIH / NCRR/RCMI Grant 2G12 RR03061-16 (Principal Investigator – E. Cadman).
Co-Investigator, Hawaii Adult AIDS Clinical Trials Unit. NIH / NIAID 5U01 A134853-08 (Principal Investigator – C. Shikuma).
Investigator, Autonomic function and insulin resistance in a multiethnic population. NIH/NINDS/NCRR Grant 1-S11 NS043364-01A1 (Principal Investigator – A. Grandinetti).
Investigator, Niaspan and Co-Factors for Lipoatrophy. Excellence in Paartnership for Community Outreach, Research on Health Disparities and Training (EXPORT Project) NIH / NCMHHD Grant # P20 MD000173-01 (Principal Investigator – C. Shikuma).
|
| Completed Awards |
Principal Investigator of project, HARC 023: Autonomic Function in HIV-1 Infected Individuals Receiving Highly Active Anti-retroviral Therapy With Abdominal Adiposity. NIH / NCRR Grant P20 RR11091(Principal Investigator – E. Cadman).
Principal Investigator, Association of Ethnicity and Gender with HIV-1 RNA levels and CD4+ Counts in HIV-Infected Individuals in Hawaii. Hawaii Community Foundation, Reference Proposal # 20020714.
Principal Investigator of project, HACRP 001: Determination of Fat Distribution in HIV-1 Infected Individuals Treated With Extended-Release Niacin (Niaspan â ). NIH / NCRR Grant P20 RR11091(Principal Investigator – E. Cadman).
Co-Investigator, An Open label pilot study of the safety and tolerance of extended-release niacin (Niaspan â ) for the treatment of hypertriglyceridemia in patients with HIV-1 infection receiving highly active anti-retroviral therapy. Queen Emma Research Fund SCR2000-12 (Principal Investigators – D. Chow and S. Souza) .
Co-Investigator, Selective excellence in health-related research activity 3: Retrovirology – Clinical Program. NIH 2g12RR/AI03061-14 (Principal Investigators – Mortimer).
Co-Investigator, Use of SPECT as a non-invasive alternative to liver biopsies in assessing liver involvement in patients co-infected with HIV and HCV. Hawaii Community Foundation Reference Proposal ID # 992721 ( Principal Investigators – B. Shiramizu) .
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| Grants Not Funded |
Principal Investigator, The effects of antiretroviral therapy on the autonomic nervous system. NIH / NINDS Proposal # S11 NS048829-01.
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Ad Hoc Reviewer
Publications
Journals
- Fo CS, Chow DC, Grandinetti A. Correlation Between Lipid Profiles And Indices of Insulin Resistance in Non-Diabetic Asian/Pacific Islanders in the Kohala Health Research Study. McGill Journal of Medicine, Under Review 2005.
- Chow D , Wood R, Grandinetti A, Shikuma C, Schatz I, Low P. Autonomic dysfunction in HIV associated adipose redistribution syndrome. Clinical Autonomic Research, Under Review 2005.
- Dinh CH, Ng R, Joffe A, Chow DC. Correcting the anion gap for hypoalbuminemia does not improve the detection of lactic acidosis. The Journal of Trauma, Injury, Infection and Critical Care , Under Review 2005.
- Grandinetti A, Seifried A, Theriault A, Chow D, Chang H, Low P. Angiotensin-converting enzyme is associated with prolonged QTc in a multiethnic population. Circulation, Under Review 2005.
- Shimizu S, Chow D, Katz A, Miller D. Association of Demographic Factors with CD4 Cell Counts and Disease Progression in HIV-infected Individuals Living in Hawaii. Ethnicity and Disease, Accepted 2005.
- Misailidis J, Dodd A, Kwock D, Chow D. Case Report: A 17-year-old Part-Native Hawaiian female with murine typhus. Hawaii Medical Journal, Accepted 2005.
- Lau M, Shea W, Chow D.Emphysematous pyelonephritis: A case report and review of the literature. Hawaii Medical Journal 2005;64:14-17.
- Walsh EJ, Souza SA, Gerschenson M, Shikuma C, Chow D. HIV Disease Progression and Limited Antiretroviral Treatment Options for a HIV-1 Infected Individual with Myoclonic Epilepsy Associated with Ragged Red Fibers. Mitochrondion 2004;4: 169-173.
- Chow DC , Souza S, Chen R, Richmond-Crum S, Grandinetti A, Shikuma C. Elevated blood pressure in HIV-infected individuals receiving Highly Active Anti-Retroviral Therapy. HIV Clinical Trials 2003; 4: 411-416.
- Theodore D, Bassett R, Coel M, Sherman K, Glesby M, Chow DC, Brobst S, Alston B, Colquhoun D, Shiramizu B. Correlation Of Single Photon Emission Computed Tomography (SPECT) Parameters With Liver Biopsies In The Setting Of HIV And HCV Co-Infection: A Multicenter Trial Of The Adult AIDS Clinical Trials Group (ACTG). JAIDS 2003; 33:329-335.
- Chow DC , Richmond-Crum SM, Shimizu SM, Kohatsu J, Souza SA, Grandinetti A, Urada KK, Shikuma C. A descriptive epidemiologic study of HIV-infected individuals in Hawaii: report of the Hawaii sero-positivity and medical management database (HSPAMM). Hawaii Medical Journal 2002; 61:275-9.
- Chow D , Souza S, Richmond-Crum S, Shikuma C. Epidemiologic evidence of increasing blood pressure in HIV-1 infected individuals in the era of HAART. Antiviral Therapy 2000; 5 (Supplement 5): 31.
- Conlin P, Chow D, Miller ER, Svetkey LP, Lin PH, Harsha DW, Moore TJ, Sacks FM, Appel LJ. The effect of dietary patterns in hypertensive patients: subgroup analysis from the Dietary Approaches to Stop Hypertension (DASH) Trial . DASH Collaborative Research Group. American Journal of Hypertension 2000; 13: 949-55.
- Chow D , Oliva O. Sylvatic Yellow Fever Outbreak in Bolivia. EPI Newsletter 1999 February; 21(1): 1-3.
- Chow DC , Babaian M, Taubin H. Jejunoileal diverticulosis. Gastroenterologist 1997; 5:78-84.
- Babaian M, Chow DC, Soloway G, Taubin H. Colonic ischemic stricture presenting as a late complication of the hemolytic uremic syndrome. Journal of Clinical Gastroenterology 1997; 25: 555-6.
- Chow DC , Sheikh S, Roberts I. A case of corrosive acid ingestion. Consultant 1996; 36:1155-8.
- Chow DC , Sheikh S, Eickoff L, Soloway G, Saul Z. Primary esophageal lymphoma in AIDS presenting as a non-healing ulcer. American Journal of Gastroenterology 1996;91:602-3.
- Chow DC . AIDS in Thailand: A medical student’s perspective. Journal of Community Health 1994;19:417-31.
Books
- Chow D . Myopathy and Myositis. In: Yamamoto LG, Inaba AS, Okamoto JK, Patrinos ME, Yamashiroya VK, eds. Pediatrics for Medical Students and Residents. Honolulu: AuthorHouse, 2004. (can be viewed at www.hawaii.edu/medicine/pediatrics )
- Chow DC , Day LJ, Shikuma CM. Metabolic Complications of HIV Therapy. In: Peiperl L, Volberding PA, eds. HIV InSite Knowledge Base [textbook on-line], revised 2003.Available at http://hivinsite.ucsf.edu/InSite.jsp?page=kb-03-02-10.
- Contributor : Healthy People 2010; Volume One. U.S. Department of Health and Human Services. Healthy People 2010 (Conference Edition, in Two Volumes). Washington, DC: January 2000.
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- Chow D , Grandinetti A, Wood R, Schatz I, Low P. Heart rate variability in HIV associated lipodystrophy. Nineth RCMI International Symposium on Health Disparities, Baltimore, MD, December 2004.
- Grandinetti A , Chow DC, Schatz I, Low P. Heart rate variability and Q-SART in a multiethnic population: preliminary findings. American Autonomic Society Meeting, Amsterdam, Holland, October 2004.
- Chow D , Grandinetti A, Wood R, Schatz I, Low P. Heart rate variability in HIV associated lipodystrophy. American Autonomic Society Meeting, Amsterdam, Holland, October 2004.
- Shimizu SM , Chow D, Richmond-Crum S, Katz A, Shikuma S, Miller DW. Association of Demographic Factors with CD4+ Cell Counts and Disease Progression in HIV-infected Individuals. Preventive Medicine 2004, Orlando, FL, February 2004.
- Chow D , Grandinetti A, Wood R. Autonomic dysfunction in HIV lipodystrophy. 4th Annual Conference of Specialized Neuroscience Research Programs at Minority Institutions, Nashville, TN, May 2004.
- Kijpittayarit S , Chow D, Souza SA, Shikuma C. Creatine Kinase Elevation in HIV Infected Patients Startedon Antiretroviral Therapy. 2004 Hawaii Chapter Scientific Meeting of the American College of Physicians. Honolulu, HI, March 2004
- Kepler K , Souza SA, Chow D. Treatment of Lipodystrophy with Extended-release Niacin in HIV-infected Individuals. 2004 Hawaii Chapter Scientific Meeting of the American College of Physicians. Honolulu, HI, March 2004.
Shimizu S, Chow D, Katz A, Miller D. Association of Demographic Factors with CD4 Cell Counts and Disease Progression in HIV-infected Individuals Living in Hawaii. 2004 Hawaii Chapter Scientific Meeting of the American College of Physicians. Honolulu, HI, March 2004.
- Gerschenson M ., Walsh EJ, Chow D, Souza S, Shiramizu B, Shikuma
C. HIV disease progression and limited antiretroviral treatment options for
an HIV-1 infected MERRF patient, Mitochondrion, Vol. 3, pg. 165, 2003.
- Chow D , Wood R, Souza S, Shikuma S, Low PA. Autonomic Dysfunction in HIV Lipodystrophy. 3rd Annual Conference of Specialized Centers in Neuroscience Excellence in Neuroscience at Minority Institutions, Honolulu, HI, May 2003.
- Grandinetti A , Chow D, Wood R, Low PA. Heart Rate Variability Differs Among Americans of Asian-Pacific Island Ancestry. 3rd Annual Conference of Specialized Centers in Neuroscience Excellence in Neuroscience at Minority Institutions, Honolulu, HI, May 2003.
- Dinh CH , Ng R, Joffe A, Chow DC. Correcting the anion gap for hypoalbuminemia does not improve the detection of lactic acidosis. American college of Physicians, Hawaii Chapter Scientific Meeting, Honolulu, HI, March 2003. Oral presentation.
- Walsh EJ , Chow DC, Souza S, Shiramizu B, and Shikuma C. HIV Disease Progression and Limited Antiretroviral Treatment Options for a HIV-1 Infected Individual with Inherited Mitochondrial Disease: A Case Report. Eighth RCMI International Symposium on Health Disparities, Honolulu, HI December 2002, PP-050.
- Shiramizu B, Ono J, Tran D, Souza S, Walsh E, Shikuma S, Chow D. Differential Changes in Hormone Sensitive Lipase and Lipoprotein Lipase Expressions Following Treatment with Niacin in Patients with HIV-Associated Lipodystrophy. Western Society of Pediatric Research, February 2003.
- Chow DC , Wood R, Subla M, Souza S, Walsh E, Marcelo ML, Shikuma C. Autonomic dysfunction in HIV lipodystrophy: A Case Report. Eighth RCMI International Symposium on Health Disparities, Honolulu, HI, December 2002, PP-038.
- Shiramizu B , Coel M, Oyadomari B, Chow DC, Hanks H, Shikuma C.Identification of Single Photon Emission Computed Tomography (SPECT) Parameters as a Noninvasive Alternative to Liver Biopsies in Subjects with HIV/HCV Co-Infection. Eighth RCMI International Symposium on Health Disparities, Honolulu, HI, December 2002, OP-083
- Theodore D , Bassett R, Coel M, Sherman K, Glesby M, Chow DC, Brobst S, Alston B, Colquhoun D, Shiramizu B. Correlation Of Single Photon Emission Computed Tomography (SPECT) Parameters With Liver Biopsies In The Setting Of HIV And HCV Co-Infection: A Multicenter Trial Of The Adult AIDS Clinical Trials Group (ACTG). American Association for the Study of Liver Diseases, Boston, MA, November 2002.
- Chow DC , Souza SA, Chen R, Richmond-Crum SM, Grandinetti A, Shiramizu B, Urada K, Shikuma C. Elevated blood pressure in HIV-infected individuals receiving highly active antiretroviral therapy. 4th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, San Diego, CA, September 2002, Abstract 53.
- Souza S , Chow DC, Walsh E, Ishimitsu D, Shikuma C. A 36-week Safety and Tolerability Study of Extended-Release Niacin (ERN) for the Treatment of Hypertriglyceridemia (HT) in Subjects with HIV. 4th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, San Diego, CA, September 2002, Abstract 49.
- Chow DC , Richmond-Crum SM, Shimizu SM, Kohatsu J, Souza SA, Grandinetti A, Urada K, Shikuma C. A Descriptive Epidemiologic Study of HIV-Infected Individuals in Hawaii: Report of the Hawaii Sero-Positivity and Medical Management Database (HSPAMM). American college of Physicians, Hawaii Chapter Scientific Meeting, Honolulu, HI, March 2002, oral presentation #2.
- Chow D , Souza S, Richmond-Crum S, Shikuma C. Epidemiologic evidence of increasing blood pressure in HIV-1 infected individuals in the era of HAART. 2 nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Toronto, Canada, 2000 Abstract # 13.
- Oliva O, Chow D. Adverse Events Following Immunization. Thirteenth Technical Advisory Group Meeting, Pan American Health Organization, Quebec, Canada, April 1999. Oral presentation.
- Oliva O, Chow D. Yellow Fever Update in the Americas. Thirteenth Technical Advisory Group Meeting, Pan American Health Organization, Quebec, Canada, April 1999. Oral presentation.
- Chow D , Miller ER, Appel LJ, et al. The effects of dietary patterns on blood pressure and control of hypertension. 71 st American Heart Association Scientific Symposium, Dallas TX, November 1998, Abstract #P366.
- Chow D , San Vicente J. Salmonella Epidural Abscess in a Patient with Chronic Lymphocytic Leukemia. 11 th Connecticut Scientific Symposium, Trumbull CT, May 1997, Poster presentation.
- Chow D , Sheikh S, Eickoff L Primary Esophageal lymphoma in AIDS presenting as a non-healing ulcer. 60 th Annual Scientific Meeting of the American College of Gastroenterology, New York NY, March 1996, Abstract # P138.
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