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Bruce Shiramizu
Professor |
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Retrovirology Research Laboratory Atherton Building, Leahi Hospital, Second Floor 3675 Kilauea Avenue, Honolulu, Hawaii 96816 TEL (808) 732-7702 FAX (808)735-3682 |
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INSTITUTION AND LOCATION |
DEGREE |
YEAR(s) |
FIELD OF STUDY |
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U. of Utah, Salt Lake City, Utah U. of Utah, Salt Lake City, Utah U. of Utah, Salt Lake City, Utah SUNY-Children's Hosp, Buffalo,NY NIH, NCI, Bethesda, MD |
BA MS MD Residency Fellow |
1977 1979 1983 1986 1989 |
Chemistry Bioengineering Medicine Pediatrics Pam Hem/Once |
| Licenses, Certifications | |
| 1983 | National Board of Medical Examiners Certificate |
| 1986-present | California State Medical License |
| 1997-present | Hawaii State Medical License |
| 1992-present | American Board of Pediatrics, Certified |
| Professional Positions:
1986-89 NIH, NCI, Bethesda, MD; Fellowship, Pediatric Hematology/Oncocolgy 1989-91 U. of California, San Francisco, Instructor, Pediatrics 1991-97 U. of California, San Francisco, Assistant Professor, Pediatrics 1997 U. of California, San Francisco, Associate Professor, Pediatrics 1989-97 San Francisco General Hospital, Staff, Pediatrics 1997-98 U. of HI, Associate Researcher, Pacific Biomedical Research Center 1997-present Co-Investigator, Hawaii AIDS Clinical Trials Unit, University of Hawaii 1998-04 U of HI, Assoc. Professor, John A. Burns School of Medicine, Pediatrics and Medicine 2000-01 U of HI, Director, Hawaii AIDS Research Consortium, RCMI Program, PBRC 2001-present U of HI, Director, Hawaii HIV & Immunobiology Lab, Hawaii AIDS Clinical Res. Prog. 2001-present U. of HI, Associate Director, Activity 4, RCMI Program 2004-present U of HI, Affiliate faculty, Cancer Research Center of Hawaii 2004-present U of HI, Professor, John A. Burns School of Medicine, Pediatrics and Medicine Honors/Awards/Certificates: 1989 New Investigator Award, UCSF Center For AIDS Research 1991 UCSF Academic Senate Faculty Development Award 1994 Physician Scientist Award, NIH, NIAID |
| Membership in Societies/Organizations | |
| 1982-97 | American Medical Association |
| 1990-97 | California State Medical Association |
| 1990-97 | San Francisco Medical Society |
| 1991-present | American Society of Pediatric Hematology/Oncology |
| 1992-present | Western Society for Pediatric Research |
| 1994-present | American Society of Hematology |
| 1994-present | American Society for Pediatric Research |
| 2002-Present | International Network for Cancer Treatment and Research |
Professional Activity: |
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| Professional Organization Activities: | |
| 1991-97 | Children's Cancer Group, Lymphoma Strategy Group |
| 1993-97 | Children's Cancer Group, Biology Research Steering Committee |
| 1991 | NIH, National Cancer Inst., Program Project Grant Review Committee |
| 1993-97 | Children's Cancer Group, CCG B944 Study Vice-Chair, Biology Studies in Childhood Hodgkin's and NHL |
| 1993-97 | Children's Cancer Group, Member, CCG 5951 Protocol |
| 1998-00 | Pediatric Oncology Group (POG), Associate Member |
| 1999-00 | Member, POG/CCG Non-Hodgkin's Lymphoma Committee |
| 2000- | Member, Children's Oncology Group (COG) |
| 2000- | Member COG Non-Hodgkin's Lymphoma Committee |
| 1999-2001 | Chair, Adult ACTG Protocol, A5096: Use of SPECT as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in Patients Co-Infected with HIV and HCV |
| 2001 | Special Emphasis Review Panel, NIAID, NIH, Pediatric AIDS Clinical Trials Program for AIDS |
| 2002 | NIH, Invited Participant in NCI Workshop on Gene-Environment Interactions in the Etiology of Childhood Cancer |
| 2003 | Faculty Committee, First International Symposium on Childhood and Adolescent Non-Hodgkin’s Lymphoma, April 10-12, 2003, New York, NY |
| 2004 | Member, Children’s Oncology Group (COG) Committee A5962 (A Pilot Study of Peripheral Blood Stem Cell Transplantation (PBSCT) following CBV Preparative Therapy in Children with Relapsed or Primarily Refractory HD & NHL--A CCG Phase II Pilot Study) |
| Other Professional Service: | |
| 1992 | The Wellcome Trust, Longdon, Reviewer for grant proposal |
| 1992-01 | Cancer Research Journal, Reviewer |
| 1994 | Blood Journal, Reviewer |
| 1997-present | Cancer Journal, Reviewer |
| 1997-01 | Journal of Pediatric Hematology/Oncology, Reviewer |
| 1999 | External grant reviewer, Cancer Research Center of Hawaii, University of Hawaii |
| 2000-present | Editorial Board, Pediatric Pathology and Molecular Medicine |
| 2001-present | Bowling Cavvine and Pharmaceutical Inc., Scientific Advisory Board Member |
| 2002-present | Cancer Research Journal, Reviewer |
| 2003-present | Pediatric Blood and Cancer Journal, Reviewer |
| 2003-present | HIV Clinical Trials, Reviewer |
| 2004 | Expert Opinion on Drug Safety, Reviewer |
| 2005-present | HIV Medicine, Reviewer |
| Scientific/Professional Meetings/Workshops Attended and Presented: | |
| Invited Papers, Lectures and Presentations (UCSF): | |
| 1989 | John Muir Medical Center Pediatric Grand Rounds |
| 1990 | UCSF, Pediatric Grand Rounds |
| 1990 | SFGH Research Conference |
| 1991 | American Cancer Society-Stanislaus Medical Center Cancer Symposium |
| 1992 | Marin General Hospital Pediatric Grand Rounds |
| 1992 | SFGH Morbidity/Mortality Conference |
| 1992 | SFGH Pediatric Grand Rounds |
| 1992 | UCSF Pediatric Grand Rounds |
| 1993 | CCG Biology Research Seminar, Symposium Speaker |
| 1993 | Research Seminar, Childresn's Hospital of Orange County, California |
| 1994 | UCSF Pediatric Grand Rounds |
| 1994 | Oakland Children's Hospital Resident Research Conference |
| 1994 | UCSF Pediatric Grand Rounds |
| 1994 | SFGH Pediatric Grand Rounds |
| 1994 | Western Pacific Congress on Chemotherapy/Infectious Diseases, Manila, Philippines, Symposium Speaker |
| 1994 | SFGH Pediatric Grand Rounds |
| 1994 | UCSF Pediatric Resident Conference |
| National AIDS Malignancy Conference, Bethesda, MD | |
| 1997 | Morehouse Medical College Research Seminar, Atlanta, GA |
| International Society for Pediatric Research, Istanbul, Turkey | |
| City of Hope Medical Center, CA Research Seminar, Duarte, CA | |
| Children's Hospital of LA Research Seminar | |
| American Society of Pediatric Hem/Onc, San Francisco, CA | |
| Invited Papers, Lectures, Presentations (U. of Hawaii): | |
| 1998 | Tripler NICU Research Seminar, Honolulu, HI, Pediatric HIV Malignancies, Jan. 23 |
| 1999 | JABSOM 2nd Year Conference, UH Manoa, HIV and Oncongenes, Feb. 17 Dept. Peds Grand Rounds, KMCWC, Minimal Residual Disease in Childhood Leukemia, April 29 3rd AIDS Malignancy Conf., Novel Intergration Sites in Pediatric Malignancies, May 26, Bethesda, MD JABSOM Research Week, Kapiolani Medical Center, Role of Viruses in Cancer, June 14 Community Consortium for AIDS Physicians in Hawaii, Queen's Medical Center, Sequential Neoplasia: A Novel Patogenic Mechanism in HIV-Associated Malignancies, Aug 26 University of Hawaii, Biology Department; Biology 406, Tumor Viruses, Dec 3 |
| 2000 | 4th Int. AIDS Malignancy Conf., Detection of Human Polyomavirus JC (JCV) in Pediatric HIV-Associated Cancers, May 16-19, Bethesda, MD |
| 2001 | Seminars in Tropical Medicine, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with highly active anti-retroviral therapy-associated lipodystrophy, Feb. 28, Leahi Hospital, University of Hawaii at Manoa, Honolulu, HI 8 th Conference on Retroviruses and Opportunistic Infections, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with HAART-associated lipodystrophy, Feb. 4-8, Chicago, IL Western Society for Pediatric Research Annual Meeting, Patient-specific primers for assessing residual disease in childhood non-Hodgkin’s lymphoma, Feb. 7-11, Carmel, CA Society for Pediatric Research/American Society of Pediatric Hem/Onc Thirteenth Annual Meeting, Identification of patient-specific primers to assay minimal residual disease in pediatric lymphoma, April 27-30, Baltimore, MD Pediatric Academic Societies Annual Meeting, Cerebrospinal fluid analysis for TT virus in pediatric patients with acute lymphoblastic leukemia, April 28-May 1, Baltimore, MD Inaugural Conference of Specialized Centers in Neuroscience, Role of macrophages in AIDS dementia, June 20-22, Atlanta, GA Grand Rounds, JABSOM Department of Pediatrics, Evidence for mitochondrial toxicity in HIV-treated patients. Kapiolani Women and Children Medical Center, Dec. 20 |
| 2002 | Adult AIDS Clinical Trials Group, Complications of HIV Research Agenda Committee Plenary Session, Correlation of SPECT Parameters as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in the Setting of HIV and HCV Co-Infection: A Multicenter Trial of the Adult AIDS Clinical Trials Group (ACTG), July 16, 2002, Arlington, VA 2nd Annual Conference of Specialized Programs in Neuroscience. Screening CNS specimens for site-specific HIV integration analysis by real-time PCR quantification, May 15-17, San Antonio, TX |
| 2003 | First International Symposium on Childhood/Adolescent Non-Hodgkin’s Lymphoma, April 10-12, 2003, New York; Plenary Talk, Measurement and Importance of Minimal Residual Disease in Lymphoblastic NHL 3rd Annual Conference of Specialized Programs in Neuroscience. Evidence for increased activated monocytes/macrophages in HIV seropositive individuals with dementia, May 27-29, Honolulu, HI |
Post Graduate and Continuing Education Courses Attended: |
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| 1986-present | Attended continuing education courses to maintain certification |
| University Service (UCSF): |
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| School of Medicine | |
| 1994-96 | Admissions Committee |
| 1994-97 | Member, UCSF Comprehensive Cancer Center |
| Department of Pediatrics | |
| 1989-91 | House Staff Minority Committee |
| 1991-95 | Intern Selection Committee |
| UCSF Medical Center | |
| 1994-95 | UCSF Pharmacy and Therapeutics Committee |
| San Francisco General Hospital | |
| 1989-90 | Cancer Committee, San Francisco General Hospital |
| 1992-97 | Cancer Committee, San Francisco General Hospital |
| 1993-97 | Transfusion Committee, San Francisco General Hospital |
| University Service (U. of Hawaii) |
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| University of Hawaii | |
| 2004- | U. of Hawaii at Manoa, Faculty Senate |
| 2004- | Committee on Research, U. of Hawaii at Manoa, Faculty Senate |
| 2005- | Ad Hoc Committee on Proprietary Research, U. of Hawaii Manoa Senate Executive Committee |
| John A. Burns School of Medicine | |
| 1997-01 | Co-Investigator, Hawaii AIDS Clinical Trials Unit |
| 1997-00 | Hawaii AIDS Clinical Research Program Scientific Advisory Board |
| 1997-00 | Hawaii AIDS Clinical Research Program Community Advisory Board |
| 1998-01 | Interviewer, School of Medicine Applicants |
| 1999-02 | Dept. of Pediatrics Faculty Personnel Committee |
| 2001-present | Hawaii AIDS CLinical Research Program Scientific Advisory Board |
| 2002-present | Co-Investigator, Hawaii Aids Clinical Trials Unit |
| 2003-present | Dept. of Pediatrics Resident Review Committee |
| 2004- | Dept. of Pediatrics Pacific Center for Pediatric Excellence Committee |
| 2003-present | Interviewer, School of Medicine Applicants |
| Cancer Center of Hawaii | |
| 2001 | American Cancer Society Institutional Grant Review Committee |
| 1998-01 | Clinical Research Center Scientific Advisory Committee |
| 1998- | Kapiolani Blood and Cancer Center Member |
| 2000-01 | Kapiolani Health Research Scientific Review Committee |
| 2004-present | Hawaii Pacific Health Scientific Review Committee |
| Kapiolani Women's and Children's Medical Center | |
| 1998-99 | Cancer Committee | 1998-01 | Clinical Research Center Scientific Advisory Committee |
| 1998- | Kapiolani Blood and Cancer Center Member |
| 2000-01 | Kapiolani Health Research Scientific Review Committee |
| 2004-present | Hawaii Pacific Health Scientific Review Committee |
| Public/Community Service: | |
| 1991-97 | Invited speaker for the Robert Louis Cancer Support Group |
| 1991-97 | Medical staff, Camp Okizu (pediatric oncology summer camp) |
| 1999 | Co-Editor JABSOM Department of Pediatrics Newsletter |
| 1999 | Panel Member, Hawaii Chapter, American Cancer Society Family Program |
| 1999 | Representative volunteer, Hawaii AIDS Clinical Trials Unit for the HOnolulu Pride Festival |
| 1999-01 | Member, Board of Directors, Gregory House Programs, Honolulu, HI |
| 2002 | Representative volunteer, Hawsaii AIDS Clinical Research Program, Life Foundations AIDS Walk |
| 2003 | Representative volunteer, Hawaii AIDS Clinical Research Program, HOnolulu Pride Festival Booth |
| 2001-03 | Hawaii AIDS Clinical Research Program Community Advisory Board |
| 2003- | Member of Hawaii Drug Assistance Program Mediation Board |
| 2004- | Board of Directors, Life Foundation, Honolulu, HI |
| Teaching: |
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| U. of Hawaii John A. Burns School of Medicine | |
| 1998 | BIOM 553; Unit 3 Hematology Problems: 1st Yr Medical Curriculum, Update on HIV |
| 1999 | BIOM 555; Unit 5 Life Cycle: Basic Science/Clinical Correlations; HIV and Oncogenes |
| 2000 | Grand Rounds, JABSOM Department of Pediatrics, Evidence for mitochondrial toxicity in HIV-treated patients. Kapiolani Women and Children Medical Center , Dec. 20 |
| 2001 | Seminars in Tropical Medicine, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with highly active anti-retroviral therapy-associated lipodystrophy, Feb. 28, Leahi Hospital, University of Hawaii at Manoa, Honolulu, HI |
| 2002 | PED 531; Pediatric Clerkship; Examiner |
| 2003 | TRMD 607; Neurovirology: HIV and CNS |
| 2004 | BIOM 699;Dissertation Research ( Deirdre Killebrew) PED 531; Pediatric Clerkship; Examiner Grand Rounds, JABSOM Department of Pediatrics, Assessment of Residual Disease in Childhood Lymphoma. Kapiolani Women and Children Medical Center, Aug. 5 |
| Undergraduate, Graduate, Medical Student, Resident, Research Advisor | |
| 1991-93 | Laura Campbell, MD (Ped. Hem/Onc fellow) |
| 1994-96 | Lorie Franks, MD (ped. Hem/Onc Fellow) |
| 1994 | Chi Nguyen, UC Berkeley, seniot thesis project |
| 1995 | Tauheedah Rashid, Mentor, UCSF Student Acad. Serv., NIH Summer Intern. Program |
| 1996 | Carhaine Chang, Student Res. Prog., American Ped. Society/Society for Ped. Res. |
| 1997 | Charmaine Chang, Travel Award, Western Society of Pediatric Research; Carmel, CA |
| 1997 | Phil Yin, Student Research Program, American Ped. Society /Society for Ped. Res. |
| 1997 | Stephen Chen, Student Intern Program, Pediatric AIDS Foundation |
| 1998 | Stephen Chen, Lowell Glasgow Student Award, Western Society of Pediatric Res; Carmel, CA Stephen Chen, Student Intern Program, Pediatric AIDS Foundation Alison Imrie, PhD, Adult AIDS Clinical Trials Group Minority AIDS Training Program |
| 1999 | Gerald Prieto, NIH NIDDK/ORMH National High School Student SUmemr Research Program |
| 2000 | Vani Sebasan, Student Research Program, American Ped. Society/Society for Ped. Res. Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair) |
| 2001 | Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair) |
| 2002 | Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair) |
| 2003 | Robert Durkin, Master Degree Candidate, Committee Member (Completed Degree) Matt Tuthill, Doctoral Graduate Student Dissertation Committee (Completed Degree) Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair) Jill Ono, U. of Hawaii JABSOM Summer Student; U. of Hawaii BRIN Summer Student Award Eric Eisenhardt, High School Summer Student project |
| 2004 | Jeffrey Moulton, U. of Michigan Summer Student Gregory Choate, Kapiolani Community College Summer Student Eric Eisenhardt, High School Summer Student Project Deirdre Killebrew, Doctoral Graduate Student Dissertation Committe (Chair) |
| 2005 | Deirdre Killerbrew, Doctoral Graduate Student Dissertation Committee (Chair) (Completed Degree) |
| Teaching Aids Prepared: | |
| 1992 | Compiled pediatric oncology handbook for residents |
| 1993-97 | Update for pediatric oncology handbook for residents |
| Research and Creative Activity: |
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| Patents: | |
| Date Issued | |
| 06/06/95 | McGrath MS, Herndier B, Shiramizu B. Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement. US Patent #5639600 |
| 12/03/06 | McGrath MS, Herndier B, Shiramizu B. Diagnosis of Cancer having clonal macrophage involvement. US Patent #5580715 |
| 06/01/97 | Magrath IT, Shiramizu B. Sensitive method for localizing chromosomal breakpoints. US Patent #5582973 |
| Original Articles: | |
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| Abstracts: |
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| Other Publications |
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| Current Grant Support | ||
| Avtive | ||
| U54NS-43049-02 (Cecilia Shikuma) | 10/01/01-9/30/06 | 65% |
| NINDS/NIH | $1,000,000 (direct cost/year) | |
| Project 2 of the Grant: Role of HIV-Integration in AIDS-Associated Dementia | ||
| The goal is to understand the role and pathogenesis of HIV-integration associated with neuropsychological abnormalities as AIDS progresses. The project is a collaborative effort with Dr. Suzanne Gartner at Johns Hopkins University. Role: PI of the Project 2 | ||
| 5U01 A134853 (Cecilia Shikuma) | 01/01/00-12/31/05 | 10% |
| NIAID | $1444,925 | |
| Hawaii Adult AIDS Clinical Trials Unit | ||
| Major goal is focused on large studies evaluating antiretroviral therapies, treatment and prophylaxis of opportunistic complications, and immune-based interventions in a multi-center research setting. Role: Co-Investigator | ||
| G12RR03061 (Edward Cadman) | 10/01/01-09/30/05 | 15% |
| NIH/NCRR | $56,954 (Direct costs of Project 1/year) | |
| Activity 4 in Pathobiology of AIDS-Associated disorders | ||
| The goals of this Activity are to understand the pathobiology of HIV-associated disorders Dr. Shiramizu is the PI of Project 1 looking at viral integration in HIV-associated malignancies as well as the Associate Activity Leader. Role: PI of one of the funded projects and Associate Activity Leader of Activity 4 | ||
| 1R21MH68173 (Bruce Shiramizu) | 07/01/03-06/30/06 | 10% |
| NIMH/NIH | Activated Immune Parameters Associated with HIV and Aging | |
| Activvated Immune Parameters Associated with HIV and Aging | ||
| The goal of the project is to characterize activated macrophages and determine an association with aging and dementia in HIV-infected individuals. Role: PI of the project | ||
| Pending | ||
| 1R01Mh073473 (bruce Shiramizu) | 12/01/04-11/30/09 | 40% |
| NIMH/NIH | $250,000(direct cost/year) | |
| Macrophage Activation Phenotype in HIV Dementia | ||
| The goal of the project is to determine specific phenotype of activated macrophages associated with dementia in HIV-infected. Role: PI of the project | ||
| 1S10RR020998 (Bruce Shiramizu) | 4/01/05-3/31/06 | |
| NCRR/NIH | $348,775 (direct cost/year, instrument only) | |
| FACSARIA Cell Sorter for the University of Hawaii | ||
| The goal of the project is to acquire an advanced cell sorter for the University of Hawaii for investigators to advance their research projects. Role: PI of the cost-share grant application. | ||