Bruce Shiramizu

Professor

Retrovirology Research Laboratory

Atherton Building, Leahi Hospital, Second Floor

3675 Kilauea Avenue, Honolulu, Hawaii 96816

TEL (808) 732-7702

FAX (808)735-3682

INSTITUTION AND LOCATION

DEGREE

YEAR(s)

FIELD OF STUDY

U. of Utah, Salt Lake City, Utah

U. of Utah, Salt Lake City, Utah

U. of Utah, Salt Lake City, Utah

SUNY-Children's Hosp, Buffalo,NY

NIH, NCI, Bethesda, MD

BA

MS

MD

Residency

Fellow

1977

1979

1983

1986

1989

Chemistry

Bioengineering

Medicine

Pediatrics

Pam Hem/Once

Licenses, Certifications
1983 National Board of Medical Examiners Certificate
1986-present California State Medical License
1997-present Hawaii State Medical License
1992-present American Board of Pediatrics, Certified
   
Professional Positions:

1986-89 NIH, NCI, Bethesda, MD; Fellowship, Pediatric Hematology/Oncocolgy

1989-91 U. of California, San Francisco, Instructor, Pediatrics

1991-97 U. of California, San Francisco, Assistant Professor, Pediatrics

1997 U. of California, San Francisco, Associate Professor, Pediatrics

1989-97 San Francisco General Hospital, Staff, Pediatrics

1997-98 U. of HI, Associate Researcher, Pacific Biomedical Research Center

1997-present Co-Investigator, Hawaii AIDS Clinical Trials Unit, University of Hawaii

1998-04 U of HI, Assoc. Professor, John A. Burns School of Medicine, Pediatrics and Medicine

2000-01 U of HI, Director, Hawaii AIDS Research Consortium, RCMI Program, PBRC

2001-present U of HI, Director, Hawaii HIV & Immunobiology Lab, Hawaii AIDS Clinical Res. Prog.

2001-present U. of HI, Associate Director, Activity 4, RCMI Program

2004-present U of HI, Affiliate faculty, Cancer Research Center of Hawaii

2004-present U of HI, Professor, John A. Burns School of Medicine, Pediatrics and Medicine

Honors/Awards/Certificates:

1989 New Investigator Award, UCSF Center For AIDS Research

1991 UCSF Academic Senate Faculty Development Award

1994 Physician Scientist Award, NIH, NIAID

Membership in Societies/Organizations
1982-97 American Medical Association
1990-97 California State Medical Association
1990-97 San Francisco Medical Society
1991-present American Society of Pediatric Hematology/Oncology
1992-present Western Society for Pediatric Research
1994-present American Society of Hematology
1994-present American Society for Pediatric Research
2002-Present International Network for Cancer Treatment and Research
 

Professional Activity:

Professional Organization Activities:
1991-97 Children's Cancer Group, Lymphoma Strategy Group
1993-97 Children's Cancer Group, Biology Research Steering Committee
1991 NIH, National Cancer Inst., Program Project Grant Review Committee
1993-97 Children's Cancer Group, CCG B944 Study Vice-Chair, Biology Studies in Childhood Hodgkin's and NHL
1993-97 Children's Cancer Group, Member, CCG 5951 Protocol
1998-00 Pediatric Oncology Group (POG), Associate Member
1999-00 Member, POG/CCG Non-Hodgkin's Lymphoma Committee
2000- Member, Children's Oncology Group (COG)
2000- Member COG Non-Hodgkin's Lymphoma Committee
1999-2001

Chair, Adult ACTG Protocol, A5096: Use of SPECT as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in Patients Co-Infected with HIV and HCV

2001 Special Emphasis Review Panel, NIAID, NIH, Pediatric AIDS Clinical Trials Program for AIDS
2002

NIH, Invited Participant in NCI Workshop on Gene-Environment Interactions in the Etiology of Childhood Cancer

2003

Faculty Committee, First International Symposium on Childhood and Adolescent Non-Hodgkin’s Lymphoma, April 10-12, 2003, New York, NY
Society for Pediatric Research, David G. Nathan Award Selection Committee

2004

Member, Children’s Oncology Group (COG) Committee A5962 (A Pilot Study of Peripheral Blood Stem Cell Transplantation (PBSCT) following CBV Preparative Therapy in Children with Relapsed or Primarily Refractory HD & NHL--A CCG Phase II Pilot Study)
Member, COG Non-Hodgkin Lymphoma Committee
Member, COG Committee ANHL01P1 (Phase III Study of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma ALCL with Standard APO Adriamycin, Prednisone, Vincristine versus Consolidation with a Regimen Including Vinblastine)
Member, COG Committee ANHL0121 (Phase II Study of Rituximab (IND #7028) and Ifosfamide, Carboplatin and Etoposide (ICE) Chemotherapy In Children with Recurrent/Refractory B-cell (CD20+) Non-Hodgkin Lymphoma and B-cell Acute Lymphoblastic Leukemia)
Member, COG Committee 9917 (Pilot Study of Dose Intensification of Methotrexate in Patients with Advanced Stage (III/IV) Small Non-cleaved Cell Non-Hodgkins Lymphoma and B-cell ALL)
Society for Pediatric Research, David G. Nathan Award Selection Committee

 
Other Professional Service:
1992 The Wellcome Trust, Longdon, Reviewer for grant proposal
1992-01 Cancer Research Journal, Reviewer
1994 Blood Journal, Reviewer
1997-present Cancer Journal, Reviewer
1997-01 Journal of Pediatric Hematology/Oncology, Reviewer
1999 External grant reviewer, Cancer Research Center of Hawaii, University of Hawaii
2000-present Editorial Board, Pediatric Pathology and Molecular Medicine
2001-present Bowling Cavvine and Pharmaceutical Inc., Scientific Advisory Board Member
2002-present Cancer Research Journal, Reviewer
2003-present Pediatric Blood and Cancer Journal, Reviewer
2003-present HIV Clinical Trials, Reviewer
2004 Expert Opinion on Drug Safety, Reviewer
2005-present HIV Medicine, Reviewer
 
Scientific/Professional Meetings/Workshops Attended and Presented:
 
Invited Papers, Lectures and Presentations (UCSF):
1989 John Muir Medical Center Pediatric Grand Rounds
1990 UCSF, Pediatric Grand Rounds
1990 SFGH Research Conference
1991 American Cancer Society-Stanislaus Medical Center Cancer Symposium
1992 Marin General Hospital Pediatric Grand Rounds
1992 SFGH Morbidity/Mortality Conference
1992 SFGH Pediatric Grand Rounds
1992 UCSF Pediatric Grand Rounds
1993 CCG Biology Research Seminar, Symposium Speaker
1993 Research Seminar, Childresn's Hospital of Orange County, California
1994 UCSF Pediatric Grand Rounds
1994 Oakland Children's Hospital Resident Research Conference
1994 UCSF Pediatric Grand Rounds
1994 SFGH Pediatric Grand Rounds
1994 Western Pacific Congress on Chemotherapy/Infectious Diseases, Manila, Philippines, Symposium Speaker
1994 SFGH Pediatric Grand Rounds
1994 UCSF Pediatric Resident Conference
  National AIDS Malignancy Conference, Bethesda, MD
1997 Morehouse Medical College Research Seminar, Atlanta, GA
  International Society for Pediatric Research, Istanbul, Turkey
  City of Hope Medical Center, CA Research Seminar, Duarte, CA
  Children's Hospital of LA Research Seminar
  American Society of Pediatric Hem/Onc, San Francisco, CA
 
Invited Papers, Lectures, Presentations (U. of Hawaii):
1998

Tripler NICU Research Seminar, Honolulu, HI, Pediatric HIV Malignancies, Jan. 23

Kapiolani Women and Children's Hospital Resident Conference, Pediatric Lymphoma, Jan.26

Western Society for Pediatric Research Annual Meeting, Carmel, CA
Second National AIDS Malignancy Conference, Bethesda, MD

American Association of Cancer Research Annual Meeting, New Orleans, LA
Federation of American Societies of Experimental Biology Annual Meeting, San Francisco, CA

Kapiolani Women and Children's Hospital Conference, Spenomegaly, May 18
John A. Burns School of Medicine, 1st Year Curriculum, Update on HIV, June 3

Queen's Medical Center, Infectious Disease Conf., Hematological Complications in HIV, June 22

Tropical Med/Med. Microbiol Res. Conf., Leahi Hospital, Role of HIV in Malignancies, Sept. 30.

1999 JABSOM 2nd Year Conference, UH Manoa, HIV and Oncongenes, Feb. 17
Dept. Peds Grand Rounds, KMCWC, Minimal Residual Disease in Childhood Leukemia, April 29

3rd AIDS Malignancy Conf., Novel Intergration Sites in Pediatric Malignancies, May 26, Bethesda, MD

JABSOM Research Week, Kapiolani Medical Center, Role of Viruses in Cancer, June 14

Community Consortium for AIDS Physicians in Hawaii, Queen's Medical Center, Sequential Neoplasia: A Novel Patogenic Mechanism in HIV-Associated Malignancies, Aug 26

University of Hawaii, Biology Department; Biology 406, Tumor Viruses, Dec 3

2000

4th Int. AIDS Malignancy Conf., Detection of Human Polyomavirus JC (JCV) in Pediatric HIV-Associated Cancers, May 16-19, Bethesda, MD

Society for Pediatric Research, Detection of Polymavirus JC (JCV) in Pediatric Malignancies, May 12-16, Boston, MA

American Society for Virology 19th Annual Meeting, Human Polyomavirus JC in Pediatric Malignancies, July 8-12, Ft. Collins, CO

2nde International Workshop on Adverse Drug Reactions and Lipodystrophy, Subcutaneous, adipose-tissue Mitochondrial DNA analysis from individuals with HAART associated lipodystrophy, Sept. 13-15, Toronto, Canada

3rd International Symposium on Neuro Virology, Detection of the polymavirus JC (JCV) in pediatric lymphoproliferative malignancies and solid tumors, Sept. 14-16, San Francisco, CA

2001

Seminars in Tropical Medicine, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with highly active anti-retroviral therapy-associated lipodystrophy, Feb. 28, Leahi Hospital, University of Hawaii at Manoa, Honolulu, HI

8 th Conference on Retroviruses and Opportunistic Infections, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with HAART-associated lipodystrophy, Feb. 4-8, Chicago, IL

Western Society for Pediatric Research Annual Meeting, Patient-specific primers for assessing residual disease in childhood non-Hodgkin’s lymphoma, Feb. 7-11, Carmel, CA

Society for Pediatric Research/American Society of Pediatric Hem/Onc Thirteenth Annual Meeting, Identification of patient-specific primers to assay minimal residual disease in pediatric lymphoma, April 27-30, Baltimore, MD

Pediatric Academic Societies Annual Meeting, Cerebrospinal fluid analysis for TT virus in pediatric patients with acute lymphoblastic leukemia, April 28-May 1, Baltimore, MD

Inaugural Conference of Specialized Centers in Neuroscience, Role of macrophages in AIDS dementia, June 20-22, Atlanta, GA

Grand Rounds, JABSOM Department of Pediatrics, Evidence for mitochondrial toxicity in HIV-treated patients. Kapiolani Women and Children Medical Center, Dec. 20

2002

Adult AIDS Clinical Trials Group, Complications of HIV Research Agenda Committee Plenary Session, Correlation of SPECT Parameters as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in the Setting of HIV and HCV Co-Infection: A Multicenter Trial of the Adult AIDS Clinical Trials Group (ACTG), July 16, 2002, Arlington, VA

2nd Annual Conference of Specialized Programs in Neuroscience. Screening CNS specimens for site-specific HIV integration analysis by real-time PCR quantification, May 15-17, San Antonio, TX

2003

First International Symposium on Childhood/Adolescent Non-Hodgkin’s Lymphoma, April 10-12, 2003, New York; Plenary Talk, Measurement and Importance of Minimal Residual Disease in Lymphoblastic NHL

3rd Annual Conference of Specialized Programs in Neuroscience. Evidence for increased activated monocytes/macrophages in HIV seropositive individuals with dementia, May 27-29, Honolulu, HI

 

Post Graduate and Continuing Education Courses Attended:

1986-present

Attended continuing education courses to maintain certification

 
University Service (UCSF):

School of Medicine
1994-96 Admissions Committee
1994-97 Member, UCSF Comprehensive Cancer Center
 
Department of Pediatrics
1989-91 House Staff Minority Committee
1991-95 Intern Selection Committee
 
UCSF Medical Center
1994-95 UCSF Pharmacy and Therapeutics Committee
 
San Francisco General Hospital
1989-90 Cancer Committee, San Francisco General Hospital
1992-97 Cancer Committee, San Francisco General Hospital
1993-97 Transfusion Committee, San Francisco General Hospital
 
University Service (U. of Hawaii)

University of Hawaii
2004- U. of Hawaii at Manoa, Faculty Senate
2004- Committee on Research, U. of Hawaii at Manoa, Faculty Senate
2005- Ad Hoc Committee on Proprietary Research, U. of Hawaii Manoa Senate Executive Committee
 
John A. Burns School of Medicine
1997-01 Co-Investigator, Hawaii AIDS Clinical Trials Unit
1997-00 Hawaii AIDS Clinical Research Program Scientific Advisory Board
1997-00 Hawaii AIDS Clinical Research Program Community Advisory Board
1998-01 Interviewer, School of Medicine Applicants
1999-02 Dept. of Pediatrics Faculty Personnel Committee
2001-present Hawaii AIDS CLinical Research Program Scientific Advisory Board
2002-present Co-Investigator, Hawaii Aids Clinical Trials Unit
2003-present Dept. of Pediatrics Resident Review Committee
2004- Dept. of Pediatrics Pacific Center for Pediatric Excellence Committee
2003-present Interviewer, School of Medicine Applicants
 
Cancer Center of Hawaii
2001 American Cancer Society Institutional Grant Review Committee
1998-01 Clinical Research Center Scientific Advisory Committee
1998- Kapiolani Blood and Cancer Center Member
2000-01 Kapiolani Health Research Scientific Review Committee
2004-present Hawaii Pacific Health Scientific Review Committee
 
Kapiolani Women's and Children's Medical Center
1998-99 Cancer Committee
1998-01 Clinical Research Center Scientific Advisory Committee
1998- Kapiolani Blood and Cancer Center Member
2000-01 Kapiolani Health Research Scientific Review Committee
2004-present Hawaii Pacific Health Scientific Review Committee
 
Public/Community Service:
1991-97 Invited speaker for the Robert Louis Cancer Support Group
1991-97 Medical staff, Camp Okizu (pediatric oncology summer camp)
1999 Co-Editor JABSOM Department of Pediatrics Newsletter
1999 Panel Member, Hawaii Chapter, American Cancer Society Family Program
1999 Representative volunteer, Hawaii AIDS Clinical Trials Unit for the HOnolulu Pride Festival
1999-01 Member, Board of Directors, Gregory House Programs, Honolulu, HI
2002 Representative volunteer, Hawsaii AIDS Clinical Research Program, Life Foundations AIDS Walk
2003 Representative volunteer, Hawaii AIDS Clinical Research Program, HOnolulu Pride Festival Booth
2001-03 Hawaii AIDS Clinical Research Program Community Advisory Board
2003- Member of Hawaii Drug Assistance Program Mediation Board
2004- Board of Directors, Life Foundation, Honolulu, HI
 
Teaching:

U. of Hawaii John A. Burns School of Medicine
1998

BIOM 553; Unit 3 Hematology Problems: 1st Yr Medical Curriculum, Update on HIV
Pediatrics; Neonatal Research Seminar: Pediatric HIV Malignancies
Pediatrics; Residency Teaching Conference: Pediatric Lymphoma
Pediatrics; Resident Teaching Conference: Splenomegaly
Internal Medicine Resident Teaching Conference: Hematological Complications in HIV
TRMD 690; Seminar in Tropical Medicine & Public Health: Role of HIV in Malignancies

1999

BIOM 555; Unit 5 Life Cycle: Basic Science/Clinical Correlations; HIV and Oncogenes
First Year Medical Curriculum Unit 3; Hem/Onc Subunit
Unit 5, Basic Science/Clinical Correlations Lecture, HIV and Oncogenes, Feb. 24
Biology 406, Cell Biology/Cancer Biology, Tumor Viruses, Dec. 3
CMB 800; Dissertation Committee Member for Caron Hong
Pediatric Unit 3; Hematology Sessions

2000

Grand Rounds, JABSOM Department of Pediatrics, Evidence for mitochondrial toxicity in HIV-treated patients. Kapiolani Women and Children Medical Center , Dec. 20
TRMD 690; Sem. in Tropical Medicine/Public Health: Update of HIV-associated malignancies
PED 531; Pediatric Clerkship; Examiner
BIOM 699; Dissertation Research ( Deirdre Killebrew)

2001

Seminars in Tropical Medicine, Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with highly active anti-retroviral therapy-associated lipodystrophy, Feb. 28, Leahi Hospital, University of Hawaii at Manoa, Honolulu, HI
PED 531; Pediatric Clerkship; Examiner
BIOM 512D; Introduction to Medical Student Research Elective (Nu Lu)
TRMD 690; Seminar in Tropical Medicine & Public Health
BIOM 699; Dissertation Research ( Deirdre Killebrew)
BIOL 499; Undergraduate Directed Studies ( Sheri Shimizu)

2002

PED 531; Pediatric Clerkship; Examiner
BIOM 699; Dissertation Research ( Deirdre Killebrew)
CMB 800; Dissertation Committee Member (Mat Tuthill)

2003

TRMD 607; Neurovirology: HIV and CNS
PED 531; Pediatric Clerkship; Examiner
CMB 800; Dissertation Committee Member ( Matt Tuthill)
PHRM 700; Dissertation Committee Member (Robert Durkin)
BIOM 699;Dissertation Research ( Deirdre Killebrew)

2004 BIOM 699;Dissertation Research ( Deirdre Killebrew)
PED 531; Pediatric Clerkship; Examiner
Grand Rounds, JABSOM Department of Pediatrics, Assessment of Residual Disease in Childhood Lymphoma. Kapiolani Women and Children Medical Center, Aug. 5

Undergraduate, Graduate, Medical Student, Resident, Research Advisor
1991-93 Laura Campbell, MD (Ped. Hem/Onc fellow)
1994-96 Lorie Franks, MD (ped. Hem/Onc Fellow)
1994 Chi Nguyen, UC Berkeley, seniot thesis project
1995 Tauheedah Rashid, Mentor, UCSF Student Acad. Serv., NIH Summer Intern. Program
1996 Carhaine Chang, Student Res. Prog., American Ped. Society/Society for Ped. Res.
1997 Charmaine Chang, Travel Award, Western Society of Pediatric Research; Carmel, CA
1997 Phil Yin, Student Research Program, American Ped. Society /Society for Ped. Res.
1997 Stephen Chen, Student Intern Program, Pediatric AIDS Foundation
1998 Stephen Chen, Lowell Glasgow Student Award, Western Society of Pediatric Res; Carmel, CA
Stephen Chen, Student Intern Program, Pediatric AIDS Foundation
Alison Imrie, PhD, Adult AIDS Clinical Trials Group Minority AIDS Training Program
1999

Gerald Prieto, NIH NIDDK/ORMH National High School Student SUmemr Research Program
Alison Imrie, PhD, Adult AIDS Clinical Trials Group Minority AIDS Training Program
Caron HOng, Doctoral Graduate Student Dissertation Committee
Pediatric Resident Advisor; Lisa Splittstoesser

2000 Vani Sebasan, Student Research Program, American Ped. Society/Society for Ped. Res.
Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair)
2001

Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair)
Eve Cabalo, Student Res. Program, American Ped Society/ Society for Ped Research

2002

Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair)
Matt Tuthill, Doctoral Graduate Student Dissertation Committee
Kelsey Shikuma, Student Intern Program, Elizabeth Glaser Pediatric AIDS Foundation
Paul Mick, Student Research Program, American Ped. Society/Society for Ped. Res.
Nicole Prada, Student, University of Modena, Modena Italy

2003 Robert Durkin, Master Degree Candidate, Committee Member (Completed Degree)
Matt Tuthill, Doctoral Graduate Student Dissertation Committee (Completed Degree)
Deirdre Killebrew, Doctoral Graduate Student Dissertation Committee (Chair)
Jill Ono, U. of Hawaii JABSOM Summer Student; U. of Hawaii BRIN Summer Student Award Eric Eisenhardt, High School Summer Student project
2004 Jeffrey Moulton, U. of Michigan Summer Student
Gregory Choate, Kapiolani Community College Summer Student
Eric Eisenhardt, High School Summer Student Project
Deirdre Killebrew, Doctoral Graduate Student Dissertation Committe (Chair)
2005 Deirdre Killerbrew, Doctoral Graduate Student Dissertation Committee (Chair) (Completed Degree)
 
Teaching Aids Prepared:
1992 Compiled pediatric oncology handbook for residents
1993-97 Update for pediatric oncology handbook for residents
 
Research and Creative Activity:

Patents:
Date Issued
06/06/95 McGrath MS, Herndier B, Shiramizu B. Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement. US Patent #5639600
12/03/06 McGrath MS, Herndier B, Shiramizu B. Diagnosis of Cancer having clonal macrophage involvement. US Patent #5580715
06/01/97 Magrath IT, Shiramizu B. Sensitive method for localizing chromosomal breakpoints. US Patent #5582973

Original Articles:
  • Shiramizu B, Janata J, Moss SD. Ion-selective field effect transistors with heterogeneous membranes. Analytica Chimica Acta 108:161-167 1979
  • Magrath I, Barriga F, McManaway M, and Shiramizu B. The molecular analysis of chromosomal translocations as a diagnostic, epidemiological and potentially prognostic tool in lymphoid neoplasia. J Virological Methods, 21, 275-289, 1988
  • Shiramizu B, Magrath I. Biology and treatment of small non-cleaved cell lymphoma. Oncology, 11:41-53, 1989
  • Shiramizu B, Magrath I. Localization of breakpoint on chromosome 8 by polymerase chain reaction in Burkitt's lymphoma. Blood, May 75:1848-1852, 1990
  • McManaway M, Neckers LM, Loke SL, Al-Nasser AA, Redner RL, Shiramizu BT, Goldschmidts W, Huber BE, Bhatia K, Magrath IT. Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide. Lancet, 335:808-811, 1990
  • Shiramizu B, Barriga F, Neequaye J, Jafri A, Dalla-Favera R, Neri A, Guittierez M, Levine P, Magrath I. Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: Relevance to geography and EBV association. Blood, 77:1516-1526, 1991
  • McGrath MS, Shiramizu B, Meeker T, Kaplan L, Herndier B. AIDS-associated polyclonal lymphoma: Identification of a new HIV-associated disease process. Journal of AIDS, 4:408-415, 1991
  • Meeker TC, Shiramizu B, Kaplan L, Herndier B, Sanchez H, Gimaldi JC, Baumgartner J, Rachlin J, Feigal E, Rosenblum M, McGrath MS. Evidence for molecular subtypes of HIV-associated lymphoma: Division into peripheral monoclonal lymphoma, peripheral polyclonal lymphoma, and central nervous system lymphoma. AIDS, 5:669-674, 1991
  • Shiramizu B, Herndier B, Meeker T, Kaplan L, and McGrath M. Molecular and immunophenotypic characterization of AIDS-associated EBV-negative polyclonal lymphoma. J Clin Oncol, 10:383-389, 1992
  • Herndier B, Shiramizu B, Jewett N, Aldape K, Reyes G, and McGrath MS. AIDS-associated T-cell lymphoma: Evidence for HIV-1 associated T-cell transformation. Blood, 79:1768-1772, 1992
  • Shiramizu B, McGrath MS, Herndier BG. Pathogenic role of HIV-1 in T-cell non-Hodgkin's lymphoma. Medical and Pediatric Oncology, 21:533, 1993
  • Ng VL, Hurt MH, Fein CL, Khayam-Bashi F, Marsh J, Nunes WM, McPhaul LW, Feigal E, Nelson P, Herndier BG, Shiramizu B, Reyes GR, Fry KE, McGrath MS: IgMs produced by two acquired immune deficiency syndrome lymphoma cell lines: Ig binding specificity and VH-gene putative somatic mutation. Blood, 83:1067-1078, 1994
  • Shiramizu B, Herndier B, McGrath MS: Identification of a common clonal HIV integration site in HIV-associated lymphomas. Cancer Research, 54:2069-2072, 1994
  • Shiramizu B, Campbell L: Early detection of central nervous system relapse in childhood acute lymphoblastic leukemia by polymerase chain reaction. International J of Ped Hem Onc, 1:605-610, 1995
  • Kaplan LD, Shiramizu B, Herndier B, Hahn J, Meeker TC, Ng V, Volberding PA, McGrath MS. Influence of molecular characteristics on clinical outcome in HIV-associated non-Hodgkin's lymphoma. Blood 85:1727-1735 1995
  • McGrath MS, Shiramizu B, Herndier BG. Identification of a clonal form of HIV in an early bowel associated Kaposi's sarcoma lesion: Evidence for a novel model of oncogenesis, "sequential neoplasia". JAIDS 8:379-385 1995
  • Shiramizu B. Herpesviruses and primary HIV-associated CNS lymphomas. Archives STD/HIV Res 9:99-106 1995
  • Marsh JW, Herndier B, Tsuzuki A, Ng VL, Shiramizu B, Abbey N, McGrath MS. Cytokine expression in AIDS associated large cell lymphomas. Journal of Interferon and Cytokine Research 15:261-268 1995
  • Franks L, Smith WB, Shiramizu B. Clonal analysis of an ovarian tumor: leukemic relapse or secondary malignancy? International J Ped Hem Onc, 4:415-422 1997
  • Magrath IT, Shiramizu B. Sensitive method for localizing chromosomal breakpoints. Biotechnology Advances 15:689 1997
  • McGrath MS, Herndier B, Shiramizu B. Diagnosis of cancer having clonal macrophage involvement. Biotechnology Advances 15:474 1997
  • Shiramizu B, Elbaggari A, Foran T, Gofman I, Perin N, Schleimer S. Monitoring of cerebral spinal fluid by polymerase chain reaction in children with acute lymphoblastic leukemia. International J Ped Hem/Onc, 5:475-483 1998
  • McGrath MS, Shiramizu B, Herndier BG. Clonal HIV in the Pathogenesis of AIDS Related Lymphoma. Infectious Causes of Cancer, Goedert JJ, Ed., Humana Press, Totowa, NJ, 2000
  • Shiramizu B, Wong J, Chen S. Presence of viral sequences in a subset of pediatric malignancies. International J Ped Hem/Onc, 6:403-409, 2000
  • Shiramizu B , Chang CW, Sposto R, Cairo M. Absence of human herpesvirus-6 genome by PCR in children with Hodgkin’s disease: a Children’s Cancer Group lymphoma biology study. Journal of Ped Hem/Onc, 23:282-285, 2001
  • Shikuma C, Hu N, Milne C, Yost F, Waslien C, Shimizu S, Shiramizu B. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV infected individuals with peripheral lipoatrophy. AIDS , 15:1801-1809 , 2001
  • Shikuma CM, Shiramizu B. Mitochondrial toxicity associated with nucleoside reverse transcriptase inhibitor therapy. Curr Infect Dis Rep , 3:553-560, 2001
  • Lyn D, Bennett NA, Shiramizu BT, Herndier BG, Igietseme JU. Sequence analysis of HIV-1 insertion sites in peripheral blood lymphocytes. Cell Mol Biol, 47:981-6, 2001
  • Yu Q, Shiramizu B, Nerurkar VR, Hu N, Shikuma CM, Melish ME, Cascio K, Imrie A, Lu Y, Yanagihara R. TT virus: preferential distribution in CD19+ peripheral blood mononuclear cells and lack of viral integration. J Medical Virology, 66:276-284, 2002 
  • Cabalo E, Wilkinson R, Lu NT, Shimizu S, Melish M, McClain KL, Jenson HB, Shiramizu B. Molecular Analysis and Pathology of a Second Pediatric HIV-Associated Burkitt’s Lymphoma, Pediatric Pathology and Molecular Medicine, 21:525-530, 2002
  • Shiramizu B , Yu Q, Hu N, Yanagihara R, Nerurkar V. Investigation of TT Virus in the Etiology of Pediatric Acute Lymphoblastic Leukemia. Pediatric Hematology and Oncology, 19:543-51, 2002
  • Sabesan V, Cairo MS, Lones MA, Perkins SL, Morris E, Sposto R, Van De Ven C, Shiramizu B. Assessment of minimal residual disease in childhood non-Hodgkin’s lymphoma by polymerase chain reaction using patient-specific primers. J Ped Hem/Onc, 25:109-113, 2003
  • Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. JAIDS, 32:370-374, 2003
  • Shiramizu B , Theodore D, Bassett R, Coel M, Sherman KE, Glesby MJ, Chow D, Alston B, Colquhoun D, Merigan TC, Reichman RC, Berggren R, Burning WJ, Brobst S. Correlation of SPECT Parameters as a Non-Invasive Alternative to Liver Biopsies in Assessing Liver Involvement in the Setting of HIV and HCV Co-Infection: A Multicenter Trial of the Adult AIDS Clinical Trials Group (ACTG). JAIDS, 33:329-335, 2003
  • Shiramizu B, Mick P. Epigenetic changes in the DAP-kinase CpG island in pediatric lymphoma. Medical and Pediatric Oncology, 41:527-531, 2003
  • Shiramizu B, Gartner S, Cho M, Liu Y, Pyron N, Valcour V, Shikuma C. Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reaction. Front Biosci, 9:255-261, 2004
  • Watters M, Poff PW, Shiramizu B, Holck P, Fast K, Shikuma CM, Valcour V. Symptomatic Distal Sensory Polyneuropathy in HIV After Age Fifty. Neurology62:1378-1383 , 2004
  • Killebrew D, Shiramizu B. Pathogenesis of HIV-associated non-Hodgkin lymphoma. Current HIV Research, 2:215-21, 2004
  • Killebrew D, Troelstrup D, Shiramizu B. Preferential HIV-1 integration sites in macrophages and HIV-associated malignancies. Cellular and Molecular Biology, 50:581-589, 2004
  • Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Holck P, Grove J, Sacktor N. Higher frequency of dementia in older HIV+ individuals. The Hawaii Aging with HIV Cohort. Neurology, 63: 822-827, 2004
  • Valcour V, Shiramizu B. HIV-associated dementia, mitochondrial dysfunction, and oxidative stress. Mitochondrion, 4:119-129, 2004
  • Kamemoto LE, Shiramizu B, Gerschenson M. HIV-associated mitochondrial toxicity in pregnancy, Mitochondrion,4:153-162, 2004
  • Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Grove J, Liu Y, Abd-Majid K, Gartner S, Sacktor N. Age, Apolipoprotein E4, and the risk of HIV dementia. The Hawaii Aging with HIV Cohort. J Neuroimmunol, 57:197-202, 2004
  • Shiramizu B, Perkins SL, Bergeron S, Lones M, Kelly K, Weiner M, Cairo MS, Assessing immunoglobulin heavy chain rearrangements in pediatric CD20-positive and CD20-negative classic Hodgkin disease. Clinical Lymphoma, 5:184-9, 2004
  • Valcour VG, Shikuma CM, Shiramizu BT, Williams AE, Watters MR, Poff PW, Grove JS, Selnes OA, Sacktor NC. Diabetes, Insulin Resistance, and Dementia Among HIV-1-Infected Patients. J AIDS, 38:31-36, 2005
  • Shiramizu B , Gartner S, Williams A, Shikuma C, Ratto-Kim S, Watters M, Aguon J, Valcour V. Circulating Proviral HIV DNA and HIV-Associated Dementia. AIDS, 19:45-52, 2005
  • Shikuma CM, Valcour VG, Ratto-Kim S, Williams AE, Souza S, Gerschenson M, Kim JH, Shiramizu B. HIV-associated wasting in the era of potent combination anti-retroviral therapy: A syndrome of residual HIV infection in monocytes/macrophages? Clin Inf Dis, 40:1846-8, 2005
  • Gerschenson M, Shiramizu B, LiButti DE, Shikuma CM. Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individuals. Antiviral Therapy, in press, 2005
Submitted:
  • Shiramizu B, Hu N, Frisque R, Nerurkar V. High Prevalence of Human Polyomavirus JC VPI Gene Sequences in Pediatric Malignancies. Journal of Pediatric Hematology/Oncology, Submitted 2004
Abstracts:
  • Shiramizu B and Magrath I. Breakpoint locations in Burkitt's lymphoma by polymerase chain reaction. Oncogene Meeting, Maryland, 1989
  • Herndier B, Shiramizu B, Sanchez H, Kaplan L, Meeker T, and McGrath M. Multisite molecular analysis of AIDS- associated lymphomas. VI Intl AIDS Conference, San Francisco, CA, 1990
  • Shiramizu B , Meeker T, Kaplan L, Khayam-Bashi F, Herndier B, and McGrath M. Molecular analysis of AIDS-associated lymphoma (AAL) VI Intl AIDS Conference, San Francisco, CA, 1990
  • Herndier B, Shiramizu B, Clark C, Meeker T, Kaplan L, McGrath M. Polyclonal EBV-negative lymphomas in AIDS: A new disease entity. Mod Pathol,4:73a, 1991
  • McPhaul L, Sanchez H, Shiramizu BT, Fein CL, Herndier BG, McGrath MS, Ng VL. Molecular characterization of a shared idiotype in AIDS lymphomas. University of California Universitywide AIDS Research Program, San Francisco, CA, 1991
  • Herndier BG, Shiramizu BT, Aldape KD, Jewett NE, McGrath MS. AIDS associated T-cell: HIV-1-associated transformation. FASEB Journal, Federation of American Society of Experimental Biology, Atlanta, GA, 1991
  • Herndier B, Shiramizu B, Jewett N, Young L, Reyes G, McGrath M. AIDS associated T-cell :HIV-1-associated transformation. VII International AIDS Conference, Florence, Italy, 1991
  • Kaplan L, Shiramizu B, Kahn JO, Herndier B, Meker T, Northfelt D, McGrath MS. Molecular predictors of survival in HIV associated non-Hodgkin's lymphoma. VII International AIDS Conference, Florence, Italy, 1991
  • Herndier B, Kaplan L, Meeker T, Shiramizu B, McGrath MS. EBV negative AIDS-associated B-cell lymphoma: Identification of a new HIV-associated disease process. VII International AIDS Conference, Florence, Italy, 1991
  • McGrath MS, Herndier B, Reyes G, Shiramizu B. HIV-associated T-cell lymphoma: Evidence that HIV may directly cause T cell transformation in vivo. Keystone Symposia on Molecular and Cellular Biology, Keystone, CO, March 27- April 3, 1992
  • Shiramizu B , Herndier B, Reyes G, McGrath M. HIV-associated T-cell lymphoma: evidence for monoclonal integration of a lentivirus. Blood, 80:325a American Society of Hematology, Anaheim, CA, Dec. 4-8, 1992
  • Campbell LA , Shiramizu BT. Detection of minimal residual disease in childhood leukemia. MD Fellow/Faculty Symposium on Molecular Medicine, UCSF, San Francisco, CA, 1992
  • Herndier B, Shiramizu B, Reyes G, McGrath M. HIV-associated T-cell lymphoma: monoclonal integration of a lentivirus adjacent to a protooncogene. FASEB Journal, 6:6034a, Federation of American Society of Experimental Biology, Anaheim, CA, April 5-9, 1992
  • Campbell L, Shiramizu B. Detection of minimal residual disease in childhood leukemia. Proc Am Soc Clin Oncol, 12:322, 1993
  • Shiramizu B , Herndier B, McGrath MS. Retroviral integration in HIV-associated lymphomas. International Society of Pediatric Oncology, San Francisco, CA, 1993
  • Shiramizu B , Herndier B, McGrath MS. Lentiviral integration in HIV-associated T-cell lymphomas. J Cell Biochem, 17E:267 Keystone Symposia on Molecular and Cellular Biology, Copper Mountain, CO, April 18-23, 1993
  • Shiramizu B , Herndier B, McGrath M. Evidence of HIV-1 integration in human non-B-cell malignancies. Blood, 82:385a American Society of Hematology, St. Louis, MO, Dec. 3-7, 1993
  • Shiramizu B , Nguyen C, Campbell L. Use of quantitative-competitive polymerase chain reaction in the evaluation of cerebral spinal fluid and peripheral blood in pediatric patients with acute lymphoblastic leukemia. Blood, 82:55a American Society of Hematology, St. Louis, MO, 1993
  • McGrath M, Herndier B, Shiramizu B. Monoclonal integration of HIV in human non-B-cell malignancies: evidence that HIV may cause transformation through insertional mutagenesis. J Cell Biochem,18B:137, Keystone Symposia, Hilton Head, SC Jan 23-30, 1994
  • Challinor J, Ablin A, Kramer R, Luna-Fineman S, Matthay K, Robbins E, Shiramizu B, Zoger S. A practical school-medical center liason program for children with cancer. International Society of Pediatric Oncology, Paris, France, 1994
  • Herndier B, Shiramizu B, McGrath M. Evidence for retroviral insertional mutagenesis in a subset of HIV-associated lymphomas. X International Conference on AIDS, Yokohama, Japan, 1994
  • Tsuzuki A, Herndier B, Marsh J, Ng V, Nolan T, Shiramizu B, McGrath M. Pathogenesis of AIDS-associated large cell lymphoma. X International Conference on AIDS, Yokohama, Japan, 1994
  • Herndier BG, Shiramizu B, McGrath MS. Direct role of HIV (clonal integration) in Kaposi's sarcoma. Evidence for a novel mode of pathogenesis. Blood, 84:437a American Society of Hematology, Nashville, TN, 1994
  • McGrath MS, Herndier BG, Shiramizu B. Evidence for direct HIV involvement in a broad spectrum of AIDS-associated lymphomas. Blood, 84:520a American Society of Hematology, Nashville, TN, 1994
  • Shiramizu B , Herndier B, McGrath M. Cancer and the HIV-infected host: New concept in cancer causation. JAMA-SEA Western Pacific Congress on Chemotherapy and Infectious Diseases, Manila, Philippines, 1994
  • Herndier BG, Shiramizu BT, McGrath MS. Sequential neoplasia-a novel theory of pathogenesis in HIV-associated malignancies. Proceedings AACR, 36:1181 86th Annual Meeting of the American Association for Cancer Research, Toronto, Canada, 1995
  • Shiramizu B . Herpesviruses and primary HIV-associated CNS lymphomas. ARTA (Assisted Reproductive Technology/Andrology) Conference, Ixtapa, Mexico, 1995
  • Shiramizu B , Herndier BG, McGrath MS. Clonal HIV integration in macrophages from HIV-associated lymphoproliferations. Blood 86:1510 American Society of Hematology, Seattle, WA, 1995
  • Herndier BG, Ng V, Shiramizu B, McGrath M. Role of herpesvirus (EBV and KSVH) in the pathogenesis of HIV-associated lymphoma. Blood 86:2216 American Society of Hematology, Seattle, WA, 1995
  • Franks LM, Shiramizu BT, Smith WB. Analysis of the leukemic clones from a patient with childhood acute lymphoblastic leukemia and ovarian relapse. Blood 86:3023 American Society of Hematology, Seattle, WA, 1995
  • Challinor J, Kramer R, Veatch J, Ablin A, Luna-Fineman S, Shannon K, Shiramizu B, Robbins E, Russo C, Pearl A, Matthay K. Educational liaison program for children with cancer and cancer survivors. Medical and Pediatric Oncology 27:271 International Society of Pediatric Oncology, 1996
  • Shiramizu B, Herndier B, Abby N, McGrath M. Clonal HIV is present in a wide variety of HIV-associated malignancies and cell separation studies map the clone to tumor-associated macrophages. National AIDS Malignancy Conference, April 28-30, Bethesda, MD, J AIDS and Retrovirology 14:A50, 1997
  • Mack KD, Wei R, Herndier B, Shiramizu B, Hurt M, Abby N, Gauscon R, Elbaggari A, McGrath MS. HIV-insertional cis-activation of the protooncogene c-fes in AIDS-associated lymphomagenesis. National AIDS Malignancy Conference, April 28-30, Bethesda, MD, J AIDS and Retrovirology 14:A44, 1997
  • Herndier B, Shiramizu B, Weinstein M, Ganem D, Orenstein J. KSHV latent and lytic infection in Kaposi’s sarcoma lesions and lymphoid tissue. National AIDS Malignancy Conference, April 28-30, Bethesda, MD, J AIDS and Retrovirology 1997
  • Chang C, Elbaggari A, Cairo M, Shiramizu B. Viral and clonal analysis of childhood lymphoma: a biology study of the Children’s Cancer Group (CCG). Western Society for Pediatric Research Annual Meeting, Feb. 6-7, Carmel, CA, J Investigative Medicine 1997
  • Shiramizu B , Mack KD, Wei R, Herndier B, Abby N, Gauscon R, Elbaggari A, McGrath MS. HIV-insertional cis-activation of the protooncogene c-fes in AIDS-associated lymphomagenesis. International Society of Pediatric Oncology Meeting, Sept. 23-27, Istanbul, Turkey, Medical and Pediatric Oncology 29: 318 1997
  • McGrath MS, Herndier BG, Abbey N, Ernst T, Shiramizu B. The role of clonal HIV as an insertional mutagen in a variety of HIV-associated malignancies. Second Annual Meeting of the Institute of Human Virology Sept. 15-21, 1997
  • Chen S, Szubin R, Schleimer S, Wei R, Shiramizu B. Clonal analysis of pediatric malignancies for retroviral integration. Western Society for Pediatric Research Annual Meeting, Feb. 5-7, Carmel, CA, J Investigative Medicine 46:72A, 1998
  • Shiramizu B , Chen S, Schleimer S, Szubin R, Wei R. Presence of HHV8 sequence in the analysis of pediatric malignancies. Second National AIDS Malignancy Conference, April 6-8, Bethesda, MD J AIDS and Retrovirology 17:A20, 1998
  • Herndier B, Wei R, Abbey N, Weinstein M, Mack K, Shiramizu B, McGrath M. Kaposi’s sarcoma: A multicellular, multiviral process initiated by retroviral insertional mutagenesis? Second National AIDS Malignancy Conference, April 6-8, Bethesda, MD J AIDS and Retrovirology 17:A22, 1998
  • Mack K, Wei R, Shiramizu B, Herndier B, Elbeggari A, Gascon R, Hurt M, McGrath M. Evidence for HIV mediated cis-activation of the c-fes protooncogene in a subset of AIDS associated lymphomas. Second National AIDS Malignancy Conference, April 6-8, Bethesda, MD J AIDS and Retrovirology 17:A34, 1998
  • McGrath M, Shiramizu B, McGuire D, Pulliam L, Herndier B, McGrath M. HIV-associated neoplastic dementia: A model implicating a role for clonal macrophages. Second National AIDS Malignancy Conference, April 6-8, Bethesda, MD J AIDS and Retrovirology 17:A34, 1998
  • Shiramizu B , Chen S, Schleimer S, Wei R. Viral analysis and detection of viral-integration in childhood malignancies. American Association for Cancer Research 89 th Annual Meeting, March 28-April 1, New Orleans, LA, Proceedings of the AACR, 39:136, 1998
  • Chen S, Szubin R, Wei R, Schleimer S, Shiramizu B. Retroviral integration in childhood malignancies. National Student Research Forum, April 17-19, Houston, TX, 1998
  • McGrath M, Wei R, Shiramizu B, Mack K, Abbey N, Herndier B. Sequential neoplasia: early forms and subsets of HIV disease contain macrophage-associated clonal forms of HIV that potentially drive neoplastic processes. Federation of American Societies of Experimental Biology/Experimental Biology 98, April 17-22, San Francisco, CA 1998
  • Mack K, Wei R, Shiramizu B, Herndier B, Abbey N, Gascon R, Elbaggari A, Hurt M, Earnst T, McGrath M. HIV cis-activation of the c-fes protooncogene in lymphoma associated clonal macrophages. Federation of American Societies of Experimental Biology/Experimental Biology 98, April 17-22, San Francisco, CA 1998
  • Shiramizu B, Chen S, Schleimer S. Analysis of pediatric malignancies for HIV-integration. American Pediatric Society-Society for Pediatric Research Annual Meeting, May 1-5, 1998, New Orleans, LAPediatric Research 43:138A, 1998
  • Shiramizu B , Chen S. Evidence for direct viral pathogenesis in a subset of pediatric HIV-associated malignancies. 6 th RCMI International AIDS Symposium, Nov. 15-18, San Juan, Puerto Rico 1998
  • Mack KD; Wei R; Shiramizu B; Herndier B; Elbaggari A; Gascon R; Hurt M; McGrath MS. “Sequential pathogenesis" of AIDS malignancies: clonal insertion of HIV into macrophages may serve as an early neoplastic event. Keystone Symposia on Molecular and Cellular Biology Park City, UT, March 13-19, 1998
  • Mack K, Wei R, Herndier B, Shiramizu B, Abbey N, Gascon R, Elbaggari A, Hurt M, Earnst T, McGrath M. HIV implicated in the cis-Activation of c-fes in a subset of HIV-associated lymphomas. 7th Conference on Retroviruses and Opportunistic Infections, Jan. 31-Feb. 2, San Francisco, CA 1999
  • Shiramizu B , Chen S. Novel integration of HIV within the X-linked lymphoproliferative disease candidate gene in pediatric malignancies. Pediatric Academic Societies’ Annual Meeting, May 1-4, 1999, San Francisco, CAPed Res 45:145A, 1999
  • McGrath MS, Shiramizu B, Herndier B. Sequential pathogenesis: A model implicating a role for clonal macrophages in neoplastic and degenerative HIV associated diseases. Third National AIDS Malignancy Conference, May 26-28, Bethesda, MD J AIDS and Retrovirology, 21:A30, 1999
  • Shiramizu B, Chen S, Wong J. Novel integration sites in pediatric malignancies. Third National AIDS Malignancy Conference, May 26-28, Bethesda, MD J AIDS and Retrovirology, 21:A30, 1999
  • Shiramizu B , Hu N, Yanagihara R, Nerurkar VR. Detection of Human Polyomavirus JC (JCV) in Pediatric HIV-Associated Cancers. May 16-19, 4 th Int. AIDS Malignancy Conf., Bethesda, MD, J AIDS; 23:A34, 2000
  • Shiramizu B , Hu N, Farley L, Yanagihara R, Nerurkar V. Detection of Polyomavirus JC (JCV) in Pediatric Malignancies; Pediatric Research 47:252A. Society for Pediatric Research, May 12-16, Boston, MA 2000
  • Shiramizu B , Hu N, Yanagihara R, Nerurkar VR. Human Polyomavirus JC in Pediatric Malignancies, Proceeding of American Society for Virology 19 th Annual Meeting, July 8-12, Ft. Collins, CO 2000
  • Shikuma C, Hu N, Milne C, Shiramizu B. Subcutaneous adipose-tissue mitochondrial DNA analysis from individuals with HAART associated lipodystrophy, 2 nd International Workshop on Adverse Drug Reactions and Lipodystrophy, Sept. 13-15, Toronto, Canada, Antiviral Therapy 5:5 Supplement 5, 2000
  • Shiramizu B , Hu N, Fajardo J, Nerurkar VR. Detection of the polyomavirus JC (JCV) in pediatric lymphoproliferative malignancies and solid tumors. 3 rd International Symposium on NeuroVirology, J of NeuroVirology; 6:454. Sept. 14-16, San Francisco, CA, 2000
  • Shiramizu B , Chen S. Novel integration of HIV within the X-linked lymphoproliferative (XLP) disease candidate gene in pediatric cancers. 7 th RCMI International Symposium on Health Disparities, Proceeding of the 7 th RCMI International Symposium on Health Disparities; 68, Nov. 12-15, 2000, San Juan, Puerto Rico, 2000
  • Shiramizu B , Hu N, Yanagihara R, Nerurkar VR. Human polyomavirus JC in pediatric lymphoproliferative malignancies and solid tumors. 7 th RCMI International Symposium on Health Disparities, Proceeding of the 7 th RCMI International Symposium on Health Disparities, 69, Nov. 12-15, 2000, San Juan, Puerto Rico, 2000
  • Shikuma C, Yost F, Shimizu S, Milne C, Shiramizu B. Subcutaneous adipose tissue mitochondrial DNA analysis from individuals with HAART-associated lipodystrophy. Proceedings of the 8 th Conference on Retroviruses and Opportunistic Infections, Feb. 4-8, Chicago, IL, 2001
  • Sebesan V, Cairo MS, Shiramizu B. Patient-specific primers for assessing residual disease in childhood non-Hodgkin’s lymphoma. Western Society for Pediatric Research Annual Meeting, Feb. 7-11, Carmel, CA, J Investigative Medicine: 49:78A, 2001
  • Sebesan V, Cairo MS, Shiramizu B. Identification of patient-specific primers to assay minimal residual disease in pediatric lymphoma. Society for Pediatric Research/American Society of Pediatric Hem/Onc Thirteenth Annual Meeting, April 27-30, Baltimore, MD, J Pediatric Hem/Onc: 23:A18, 2001
  • Qigui Yu Q, Nerurkar VR, Hu N, Yanagihara R, Shiramizu B. Cerebrospinal fluid analysis for TT virus in pediatric patients with acute lymphoblastic leukemia. Pediatric Academic Societies Annual Meeting, April 28-May 1, Baltimore, MD, Pediatric Research: 49:251A, 2001
  • Valcour V, Shikuma C, Shiramizu B, Sacktor N, Selnes O. Neurocognitive Function: HIV seropositivity and aging-a proposed analysis. Inaugural Conference of Specialized Centers in Neuroscience, June 20-22, Atlanta, GA, 2001
  • Shiramizu B , Gartner S. Role of macrophages in AIDS dementia. Inaugural Conference of Specialized Centers in Neuroscience, June 20-22, Atlanta, GA, 2001
  • Yu Q, Nerurkar VR, Shiramuzu B, Hu N, Shikuma C, Melish ME, Cascio K, Imrie A, Lu Y, and Yanagihara R. TT virus is preferentially distributed in CD19+ peripheral blood mononuclear cells with lack of viral integration and undetectable of viral double-stranded replicating intermediates. 20th Annual Meeting of the American Society for Virology. Madison, Wisconsin, July 14-18, 2001
  • Shiramizu B , Westgard E, Cossarizza A, Pinti M, Shikuma C. Competitive PCR-analysis of subcutaneous adipose tissue mtDNA from individuals with HAART-associated lipodystrophy. 3 rd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Oct. 23-26, Athens, Greece, 2001
  • Killebrew, D. A., Shiramizu, Bruce.  Site-Directed Mutagenesis in Human Immunodeficiency Virus – 1.  American society for Microbiology, Hawaii Branch Meeting, Honolulu, HI, 2001
  • Troelstrup DL, Shiramizu, B and McGrath, M. Preferential integration sites of HIV- I in human tumor biopsies. Annual Biomedical Sciences Symposium, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, March 22, 2002
  • Killebrew, D and Shiramizu, B. Identification of preferential HIV- I integration sites. Annual Biomedical Sciences Symposium, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, March 22,2002
  • Pyron N, Valcour, V, Gartner, S and Shiramizu, B. Correlation of HIV- I integration sites with neuropsychological parameters in HIV-infected individuals. Annual Biomedical Sciences Symposium, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, March 22, 2002
  • Westgard E, Shiramizu, B, Cossariza A, Piniti M and Shikuma CM. Mitochondrial DNA depletion in lipodystrophic HIV-infected patients. Annual Biomedical Sciences Symposium., John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, March 22, 2002
  • Cabalo E, Wilkinson R, Melish M, McClain K, Jenson H, Shiramizu B. Second HIV-Associated Malignancies in the HAART Era. Society for Pediatric Research 71 st Annual Meeting, May 4-7, 2002, Baltimore, MD, J of Ped Hem/Onc, 24:A26, 2002
  • Valcour V, Shiramizu B, Shikuma C, Poff P, Watters M, Sacktor N, Selnes O. Increased severity of cognitive impairment among older compared to younger HIV-1 seropositive individuals. 2 nd Annual Conference of Specialized Programs in Neuroscience, San Antonio, TX, May 15-17, 2002
  • Shiramizu B, Pyron N, Valcour V, Shikuma C, Gartner S. Screening CNS specimens for site-specific HIV integration analysis by real-time PCR quantification. 2 nd Annual Conference of Specialized Programs in Neuroscience, San Antonio, TX, May 15-17, 2002
  • Valcour V, Shiramizu B, Shikuma C, Poff PW, Watters M, Grove J, Selnes O, Sacktor N. Neurocognitive function among older compared to younger HIV-1 seropositive individuals. 4 th International Symposium of Neurovirology/10 th Conference on Neuroscience of HIV infection, Dusseldorf, Germany, June 18-22, 2002, Journal of NeuroVirology, 8:69, 2002
  • Shiramizu B, Pyron N, Valcour V, Poff P, Watters M, Shikuma C, Gartner S. Identification of site specific HIV integration in CNS specimens. 4 th International Symposium of Neurovirology/10 th Conference on Neuroscience of HIV infection, Dusseldorf, Germany, June 18-22, 2002, Journal of NeuroVirology, 8:84, 2002.
  • Shiramizu B, Morris E, Perkins S, Lones M, Kelly K, Weiner M, Sposto R, Cairo MS. Identification of patient specific primers (PSPs) of IgH and TCR- g regions by nested PCR in CD20 positive Hodgkin disease: A Children's Cancer Group Report (CCG). 8 th International Conference on Malignant Lymphoma, June 12-15, 2002, Lugano, Switzerland, Annals of Oncology 13:112, 2002.
  • Sanger W, Lones M, Perkins S, Heerema N, Shiramizu B, Sposto R, Davenport V, Goldman S, Cairo MS. Chromosome abnormalities in B-cell non-Hodgkin lymphoma (NHL) of children and adolescents: A report from the Children’s Cancer Group Study CCG-5961. 8 th International Conference on Malignant Lymphoma, June 12-15, 2002, Lugano, Switzerland, Annals of Oncology 13:45, 2002.
  • Theodore D, Bassett R, Coel M, Sherman KE, Glesby MJ, Chow D,Brobst SW, Alston B, Colquhoun D, Shiramizu B. Correlation of single photon emission computed tomography (SPECT) parameters with liver biopsies in the setting of HIV and HCV co-infection: A multicenter trial of the Adult AIDS Clinical Trials Group, ACTG 5096. 53rd Annual Meeting of the American Association for the Study of Liver Diseases, November 1 - 5, 2002, Boston, MA.
  • Chow D, Souza S, Chen R, Richmond-Crum S, Grandinetti A, Shiramizu B, Urada K, Shikuma CM. Elevated blood pressure in HIV-infected individuals receiving highly active anti-retroviral therapy. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 129, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Valcour V, Poff PW, Watters M, Shiramizu B, Sacktor N, Selnes O, Shikuma CM. Rates of neurocognitive dysfunction in older (50+) HIV-seropositive individuals: The Hawaii Aging with HIV Study. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 130, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Shiramizu B , Coel M, Oyadomari B, Chow D, Hanks N, Shikuma CM. Identification of single photon emission computed tomography (SPECT) parameters as a non-invasive alternative to liver biopsies in subjects with HIV/HCV co-infection. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 130, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Shikuma CM, Westcort E, Pyron N, Shiramizu B. Comparison of mitochondrial DNA content in peripheral blood mononuclear cells and subcutaneous adipose tissue in individuals with HIV-associated lipoatrophy. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 130, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Shiramizu B , Yu Q, Hu N, Nerurkar VR. Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 144, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Frederick J, Shiramizu B, Frank JE, Shikuma CM. Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as a possible mechanism for HIV viral load/CD4 count disconnect: A case report with mtDNA analysis of peripheral blood mononuclear cells. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 154, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Walsh EJ, Chow D, Souza S, Shiramizu B, Shikuma CM. HIV disease progression and limited antiretroviral treatment options for an HIV-infected individual with inherited mitochondrial disease: A case report. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 154, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Fast KM, Poff PW, Watters M, Shiramizu B, Shikuma CM, Valcour VG. Demographic characteristics of older HIV-1 seropositive individuals in Hawaii: Findings from the University of Hawaii NeuroAIDS Specialized Neuroscience Research Program. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 155, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Poff PW, Watters M, Shikuma CM, Shiramizu B, Valcour VG. Differences in neuropsychological test performance between HIV-1 seropositive Asians/Pacific Islanders and Caucasians: Findings from the University of Hawaii NeuroAIDS Specialized Neuroscience Research Program. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 155, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Troelstrup D, Jin X, Kapp L, McGrath M, Shiramizu B. Identification of site-specific integration in HIV-associated large cell lymphoma. from the University of Hawaii NeuroAIDS Specialized Neuroscience Research Program. 8 th RCMI International Symposium on Health Disparities, Proceeding of the 8 th RCMI International Symposium on Health Disparities; 161, Dec. 8-11, 2002, Honolulu, HI, 2002
  • Shikuma KM, Kamamoto L, Shikuma C, Gerschenson, Shiramizu B. Quantitative real-time PCR analysis for mitochondrial DNA toxicity in HIV-infected women receiving HAART during pregnancy. Western Society for Pediatric Research Annual Meeting, Jan. 28-Feb. 1, Carmel, CA, Journal of Investigative Medicine; 51:S161, 2003
  • Shiramizu B , Shikuma KM, Kamamoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. 10 th Conference on Retroviruses and Opportunistic Infections, Feb. 10-14, 2003, Boston, MA, 2003
  • Killebrew DA, Shiramizu B.  Identification of Preferential HIV-1 Integration Sites.  Keystone Symposia –
    Twenty Years of HIV Research and HIV Vaccine Development. March 28- April 4, Banff, Alberta, Canada, 2003
  • Killebrew DA, Shiramizu B.  Identification of Preferential HIV-1 Integration Sites.    John A. Burns School of Medicine Biomedical Sciences Symposium. April 24, 2003
  • Watters MR, Poff PW, Shiramizu BT, Shikuma CM, Valcour VG. Symptomatic distal sensory polyneuropathy (SxDSPN) in HIV after age 50. 55 th Annual Meeting American Academy of Neurology, March 29-April 5, Honolulu, HI, 2003
  • Shiramizu B, Mick P. Loss of DAP-Kinase expression with associated hypermethylation may be characteristic of a subset of pediatric B-cell malignancies. 1 st International Symposium on Childhood and Adolescent Non-Hodgkin’s Lymphoma, April 10-12, New York, NY, J Ped Hem/Onc 25:S17, 2003
  • Shiramizu B, Perkins S, Bergeron S, Lones M, Kelly K, Weiner M, Cairo M. IgH rearrangements in pediatric CD20+ classic Hodgkin disease cases by PCR. 1 st International Symposium on Childhood and Adolescent Non-Hodgkin’s Lymphoma, April 10-12, New York, NY, J Ped Hem/Onc 25:S20, 2003
  • Mick P, Shiramizu B. Epigenetic changes in the DAP-Kinase CpG Island in pediatric lymphoma. Society for Pediatric Research 72 nd Annual Meeting and American Society of Pediatric Hem/Onc 16 th Annual Meeting, May 1-5, Seattle, WA, Ped Research 53:287A, 2003
  • Shiramizu B , Cho M, Valcour V, Shikuma C, Silvia Ratto-Kim Evidence for increased activated monocytes/macrophages in HIV seropositive individuals with dementia. 3rd Annual Conference of Specialized Programs in Neuroscience, Honolulu, HI, May 27-29, 2003
  • Valcour V, Shikuma C, Shiramizu B, Watters M, Sacktor N. M RI White Matter Changes (WMC) in older HIV+ individuals with dementia. 3rd Annual Conference of Specialized Programs in Neuroscience, Honolulu, HI, May 27-29, 2003
  • Valcour V, Shikuma C, Shiramizu B, Watters M, Poff P, Selnes O, Sacktor N. Metabolic and vascular risk factors associated with HIV dementia in older seropositive patients. 5 th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV; July 8-11, Paris, France, 2003
  • Shiramizu B , Gartner S, Cho M, Liu Y, Shikuma C, Watters M, Valcour V. HIV DNA Levels in Circulating Cells and Neurocognitive Abnormalities. 5 th International Symposium of Neurovirology, Baltimore, MD, Sept. 4-7, 2003, Journal of NeuroVirology, 9:Supp l 3, 137-138, 2003
  • Shiramizu B , Cho M, Aguon J, Shikuma C, Valcour V, Ratto-Kim S. Presence of CD14/16-Positive Monocytes/Macrophages in Older HIV Seropositive Individuals with Dementia. 5 th International Symposium of Neurovirology, Baltimore , MD , Sept. 4-7, 2003, Journal of NeuroVirology, 9:Suppl 3, 25, 2003
  • Valcour V, Gartner S, Liu Y, Shiramizu B, Shikuma C, Grove J, Selnes O, Sacktor N. Varying effect of ApoE allele expression with age associated with HIV dementia. 5 th International Symposium of Neurovirology, Baltimore, MD, Sept. 4-7, 2003, Journal of NeuroVirology, 9:Suppl 3, 25, 2003
  • Gerschenson M, Walsh E.J, Chow D, Souza S, Shiramizu B, Shikuma C. HIV disease progression and limited antiretroviral treatment options for an HIV-1 infected MERRF patient, Mitochondrion, 3:165, 2003
  • Gerschenson M, Shiramizu B, Shikuma KM, Kamemoto L, Erdem G, Pinti A, Cossarizza A, Shikuma C. Placental cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy, Mitochondrion, 3:161, 2003
  • Ono J, Souza S, Walsh E, Chow D, Tran D, Shikuma C, Shiramizu B . Effects of niacin on hormone sensitive lipase and lipoprotein lipase expression in patients with human immunodeficiency virus-lipodystrophy syndrome. Western Society for Pediatric Research Annual Meeting, Jan. 29-31, Carmel, CA, J Investigative Medicine, 52(1):S127, 2004
  • Killebrew DA, Troelstrup D, Shiramizu B. Identification of Preferential HIV-integration Sites in Macrophages and HIV-associated Malignancies, 11 th Conference on Retroviruses and Opportunistic Infections, Feb. 8-11, San Francisco, CA, 2004
  • Valcour V, Shikuma C, Shiramizu B, Grove J, Watters M, Poff P, Selnes O, Sacktor N. Diabetes and Cognitive Functioning Among HIV Seropositive Patients. The Hawaii Aging with HIV Cohort. 11 th Conference on Retroviruses and Opportunistic Infections, Feb. 8-11, San Francisco, CA, 2004
  • Gerschenson M, Shiramizu B, Tran D, O'Callaghan C, LiButti DE, Shikuma CM. Mitochondrial DNA depletion in adipose tissues but not PBMC correlate with lipoatrophy in HIV-infected patients. 11 th Conference on Retroviruses and Opportunistic Infections, Feb. 8-11, San Francisco, CA, 2004
  • Tran D, LiButti DE, Shikuma CM, Shiramizu B, Gerschenson M. Mitochondrial DNA levels vary in subcutaneous adipose tissue from HIV-infected patients. John A. Burns School of Medicine Biomedical Sciences Symposium. April 30, 2004
  • Ono J, Souza S, Walsh E, Chow D, Tran D, Shikuma C, Shiramizu B. Effects of niacin on hormone sensitive lipase and lipoprotein lipase expression in patients with human immunodeficiency virus-lipodystrophy syndrome. John A. Burns School of Medicine Biomedical Sciences Symposium. April 30, 2004
  • Killebrew DA, Troelstrup D , Shiramizu B. Preferential HIV-integration sites: Possible first step in sequential neoplasia. American Association for Cancer Research Annual Meeting, March 27-31, Orlando, FL, 2004
  • Shiramizu B, Troelstrup D, Aguon J, Killebrew D, Sapalo D, Ratto-Kim S, Williams A, Shikuma C, Valcour V. Association of Chemokines/Cytokines from Macrophage Supernatants and Cerebrospinal Fluid with HIV-Associated Dementia. 4th Annual Conference of Specialized Neuroscience Research Programs, May 19-22, Nashville, TN, 2004
  • Ratto-Kim S, Aguon J, Williams A, Williams K, Shikuma C, Valcour V, Shiramizu B. Membrane Markers on Peripheral Leukocytes in HIV Associated Dementia. 4th Annual Conference of Specialized Neuroscience Research Programs, May 19-22, Nashville, TN, 2004
  • Valcour V, Shikuma C, Shiramizu B, Williams A, Watters, Sacktor N. Diabetes and cognition among older HIV patients. 4th Annual Conference of Specialized Neuroscience Research Programs, May 19-22, Nashville, TN, 2004
  • M. Gerschenson, D.E. LiButti, D. Tran, B. Shiramizu, L. Day, M. Marcelo, C.M. Shikuma. Mitochondrial therapies for HIV lipoatrophy. Mitochondrial Medicine 2004 Pittsburgh Meeting, August 4-8, Pittsburgh, PA, 2004
  • Valcour V, Shikuma C , Shiramizu B, Williams AE, Watters M, Selnes O, Poff P, Sacktor N. Insulin resistance may be a new marker of HAD in the era of HAART. 6 th International Symposium of Neurovirology, Sardinia, Italy, Sept. 9-10, 2004, Journal of NeuroVirology, 2004
  • Shiramizu B , Aguon J, Williams A, Williams K, Shikuma C, Valcour V, Ratto-Kim S. CD14hi/CD16lo monocyte/macrophage and T-lymphocyte phenotypes in individuals with HIV-associated dementia. 6 th International Symposium of Neurovirology, Sardinia, Italy, Sept. 9-10, 2004, Journal of NeuroVirology, 2004
  • Killebrew D, Troelstrup D, Valcour V, Williams A, Aguon J, Sapalo D, Shikuma C, Ratto-Kim S, Shiramizu B. Discordant plasma and cerebral spinal fluid cytokines/chemokines in relation to HIV-1-associated dementia, 9 th RCMI International Symposium on Health Disparities, Proceeding of the 9 th RCMI International Symposium on Health Disparities; Dec. 9-12, 2004, Baltimore, MD, 2004
  • Shiramizu B , Gartner S, Williams A, Shikuma C,Ratto-Kim S, Watters M, Valcour V. Peripheral HIV-1 DNA Copy Number and HIV-1 Associated Dementia. 12 th Conference on Retroviruses and Opportunistic Infections, Feb. 22-25, Boston, MA, 2005
  • J Lloyd, DE LiButti, B Shiramizu, CM Shikuma, M Gerschenson, Platelet contamination affects mitochondrial DNA levels in peripheral blood mononuclear cells from HIV patients. FASEB Experimental Biology Annual Meeting, April 2-6. San Diego, CA, The FASEB Journal, 19 (4): A827, 2005
Other Publications
  • Barriga F, Kiwanuka J, Alvarez-Mon M, Shiramizu B, Huber B, Levine P, Magrath I. Significance of chromosome 8 breakpoint location in Burkitt's lymphoma: correlation with geographical origin and association with Epstein-Barr virus. Current Topics in Microbiology and Immunology, 141, 128-137, 1988
  • Kiwanuka J, Shiramizu B, Sandlund T, Barriga F, McManaway M, Novikovs L, Huber B, Magrath IT. The contribution of Burkitt's lymphoma cell lines to the understanding of the pathogenesis of Burkitt's lymphoma. Cancer Reviews, 10, 63-91, 1988
  • Shiramizu B , McGrath MS. Molecular pathogenesis of AIDS-associated non-Hodgkin's lymphoma. Hematology/Oncology Clinics of North America, Mitsuyasu RT and Golde DW, Eds. 5:323-330, 1991
  • Herndier BG, Shiramizu BT, and McGrath MS. AIDS-associated non-Hodgkin's lymphomas represent a broad spectrum of monoclonal and polyclonal lymphoproliferative processes. Current Topics in Microbiology and Immunology, 182:385-394, 1992
  • McGrath MS, Shiramizu B, Herndier BG. AIDS and non-Hodgkin's lymphoma: A pre-pre-B-cell monoclonal lymphoma vs. a novel mechanism of polyclonality? (Letter) J Clin Oncol, 10:1650-1651, 1992
  • Gunthel C, Ng V, Herndier V, McGrath MS and Shiramizu B. Association of Epstein-Barr virus types 1 and 2 with AIDS-related CNS lymphomas (Letter). Blood, 83:618-619, 1994
  • Grossman M, Shiramizu B. Evaluation of lymphadenopathy in children. Current Opinion Pediatrics, 6:68-76, 1994
  • Shiramizu B , DeSantes K. Pediatric protocols, in Ignoffo B, Venook A, Damon, L, Viele C (eds): Cancer Chemotherapy Pocket Guide. Lippincott-Raven, Philadelphia, 1997
  • McGrath MS, Shiramizu B, Herndier BG. Clonal HIV in the pathogenesis of AIDS-related lymphoma: Sequential pathogenesis. In: Infectious Causes of Cancer: Targets for Intervention, Goedert JJ, (ed); Humana Press, Totowa, NJ, pp 231-242, 2000
  • Gerschenson M, Shikuma C, Shiramizu B. Mitochondria are multi-hit by antiretroviral therapy causing the HIV-lipodystrophy syndrome. MitoMatters: Mitochondria Research Society 1:3-6, 2002
  • Shikuma C, Souza S, Shiramizu B. Pathogenesis of HIV Lipdystrophy, in Wanke CA, Gorbach SL (eds): Lipodystrophy Syndrome in HIV. Kluwer Academic Publishers, Boston, 2003
  • Hernandez B, Shiramizu B. Viruses and Cancer. Hawaii Medical Journal, 64:106-108, 2005
  • Shiramizu B , Okano Motohiko, Gross T. Human Immunodeficiency Virus-Associated Non-Hodgkin Lymphoma in Liberman AP (ed): Progress in AIDS Research. Nova Science Publishers, Hauppauge, NY, Chapter 3, 61-79, 2005
  • Ono J, Shiramizu B. New Insights in Pediatric Hodgkin’s Disease, in Heinz BC (ed): Trends in Hodgkin’s Disease Research. Nova Science Publishers, Hauppauge, NY, 2005
  • Shiramizu B. in Yamamoto LG, Inaba AS, Okamoto JK, Patrinos ME, Yamashiroya VK (eds): Case Based Pediatrics For Medical Students and Residents, 2004 (In press)
Current Grant Support
Avtive
U54NS-43049-02 (Cecilia Shikuma) 10/01/01-9/30/06 65%
NINDS/NIH $1,000,000 (direct cost/year)
Project 2 of the Grant: Role of HIV-Integration in AIDS-Associated Dementia
The goal is to understand the role and pathogenesis of HIV-integration associated with neuropsychological abnormalities as AIDS progresses. The project is a collaborative effort with Dr. Suzanne Gartner at Johns Hopkins University. Role: PI of the Project 2
 
5U01 A134853 (Cecilia Shikuma) 01/01/00-12/31/05 10%
NIAID $1444,925
Hawaii Adult AIDS Clinical Trials Unit
Major goal is focused on large studies evaluating antiretroviral therapies, treatment and prophylaxis of opportunistic complications, and immune-based interventions in a multi-center research setting. Role: Co-Investigator
 
G12RR03061 (Edward Cadman) 10/01/01-09/30/05 15%
NIH/NCRR $56,954 (Direct costs of Project 1/year)
Activity 4 in Pathobiology of AIDS-Associated disorders
The goals of this Activity are to understand the pathobiology of HIV-associated disorders Dr. Shiramizu is the PI of Project 1 looking at viral integration in HIV-associated malignancies as well as the Associate Activity Leader. Role: PI of one of the funded projects and Associate Activity Leader of Activity 4
 
1R21MH68173 (Bruce Shiramizu) 07/01/03-06/30/06 10%
NIMH/NIH Activated Immune Parameters Associated with HIV and Aging
Activvated Immune Parameters Associated with HIV and Aging
The goal of the project is to characterize activated macrophages and determine an association with aging and dementia in HIV-infected individuals. Role: PI of the project
 
Pending
1R01Mh073473 (bruce Shiramizu) 12/01/04-11/30/09 40%
NIMH/NIH $250,000(direct cost/year)
Macrophage Activation Phenotype in HIV Dementia
The goal of the project is to determine specific phenotype of activated macrophages associated with dementia in HIV-infected. Role: PI of the project
1S10RR020998 (Bruce Shiramizu) 4/01/05-3/31/06
NCRR/NIH $348,775 (direct cost/year, instrument only)
FACSARIA Cell Sorter for the University of Hawaii
The goal of the project is to acquire an advanced cell sorter for the University of Hawaii for investigators to advance their research projects. Role: PI of the cost-share grant application.