Limahuli ahupua‘a on the island of Kaua‘i.The Pacific Biosciences Research Center is a center of excellence in interdisciplinary biological sciences, with its research, training, and outreach activities focused on the unique opportunities found in Hawaiʻi and throughout the Pacific Islands.  PBRC has received national and international recognition as a leader in integrated mountain-to-sea science, and uses as its guiding principle the concept of the Hawaiian ahuhpuaʻa, a self-sustaining unit highlighting the interrelationship between land and sea, and a communal responsibility for the land.  PBRC follows the ethic of sustainability with respect for the culture, values, and limited natural resources of Hawaiʻi.